Increased fat synthesis and limited apolipoprotein B cause lipid accumulation in the liver of broiler chickens exposed to chronic heat stress

Poultry Science
Zhuang LuF Gao

Abstract

Chronic heat stress can enhance fat synthesis in broilers, and excessive triglyceride (TG) synthesized by the liver needs to be transported to extrahepatic tissues by very low density lipoprotein (VLDL) otherwise will accumulate in the liver, which may even result in hepatic steatosis. To investigate the molecular mechanisms by which chronic heat stress enhances fat synthesis and results in lipid accumulation in the liver of chickens, 144 broilers (Arbor Acres, 28-day-old) were randomly allocated to the normal control (NC, 22°C), heat stress (HS, consistent 32°C), or pair-fed (PF, 22°C) groups for a 14-D trial. The 7 D of heat exposure significantly increased the respiratory rate, relative weight of abdominal fat, the levels of glucose, TG, corticosterone, insulin, and VLDL in plasma, as well as the levels of TG, total cholesterol, acyl-CoA carboxylase (ACC), and fatty acid synthase (FAS) in the liver, and mRNA expression levels of carbohydrate response element-binding protein (ChREBP), ACC, FAS, and microsomal triglyceride transfer protein (MTTP) in comparison with the other 2 groups. After 14 D of heat exposure, the relative weights of abdominal fat and liver and levels of TG and FAS in the liver were significantly higher in ...Continue Reading

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Citations

Oct 25, 2020·Environmental Science and Pollution Research International·Yan GuoWen-Chao Liu
Mar 7, 2021·Animals : an Open Access Journal From MDPI·Chang YinHongfu Zhang
Aug 11, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Zhuo-Hui LuoXiao-Ling Shen
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Darae Kang, Kwanseob Shim
Oct 7, 2021·Tropical Animal Health and Production·Muhammad Adnan AslamӦzay Güleş
May 16, 2020·Food Chemistry·Lan LiuQun Huang

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