Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression

The Prostate
Ellen S PizerJ B Nelson

Abstract

Fatty acid synthase (FAS) performs the anabolic conversion of dietary carbohydrate or protein to fat. FAS expression is low in most normal tissues, but is elevated in many human cancers, including androgen-sensitive and androgen-independent prostate cancer. Immunohistochemical evaluation of FAS expression was performed in human prostate cancer specimens under various states of androgen ablation. In vitro and in vivo prostate cancer models were evaluated for FAS expression and activity under androgenic and androgen-depleted conditions, and were tested for sensitivity to antimetabolite drugs that target fatty acid synthesis. While FAS expression in the prostate was androgen responsive, it persisted or was reactivated in human prostate carcinoma after androgen ablation, and was high in 82% of lethal tumors examined at autopsy. Similar patterns of FAS expression and fatty acid synthesis were seen in cell culture and xenograft models of human prostate cancer. Pharmacologic inhibition of FAS resulted in a dose-dependent reduction of tumor growth in these models, including fourfold inhibition of an androgen-independent human prostate cancer xenograft with little associated toxicity. The data suggest that FAS expression/FA synthesis pr...Continue Reading

References

May 1, 1992·American Journal of Clinical Pathology·M S ShurbajiT S Thurmond
Nov 1, 1992·Andrologia·F VignonP Reville
Sep 7, 1989·The New England Journal of Medicine·F P KuhajdaG R Pasternack
Nov 15, 1989·International Journal of Cancer. Journal International Du Cancer·A R BrothmanD J Merchant
Jun 1, 1987·The Journal of Urology·T IizumiK Koiso
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·J V SwinnenG Verhoeven
May 15, 1998·The Prostate·B O NilssonG Ronquist
Apr 18, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T KusakabeT Suzuki

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Citations

Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Johannes V SwinnenGuido Verhoeven
Mar 6, 2007·World Journal of Urology·Thorsten SchlommGuido Sauter
Sep 13, 2007·Cancer Metastasis Reviews·Yong Q ChenIsabelle M Berquin
Aug 2, 2003·Molecular and Cellular Endocrinology·Hannelore HeemersJohannes V Swinnen
Jun 12, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Shengjun QiaoPentti Tuohimaa
Jul 10, 2007·Nature Structural & Molecular Biology·Charles W PembleW Todd Lowther
Apr 15, 2011·The Journal of Biological Chemistry·James Robert Krycer, Andrew John Brown
Aug 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul L NguyenMassimo Loda
Jun 11, 2008·Journal of Zhejiang University. Science. B·Wei-qin WangYun Liang
Mar 31, 2012·Archives of Pathology & Laboratory Medicine·George J Netto, Liang Cheng
Mar 22, 2003·Lancet·Angelo M DeMarzoJonathan I Epstein
Dec 18, 2013·Virchows Archiv : an International Journal of Pathology·Kosuke MiyaiHitoshi Tsuda
Jan 30, 2013·Biochimica Et Biophysica Acta·James Robert Krycer, Andrew John Brown
Mar 20, 2014·Japanese Journal of Clinical Oncology·Shinsuke HamadaKeiichi Iwaya
Mar 8, 2014·World Journal of Gastroenterology : WJG·Julian SwierczynskiTomasz Sledzinski
Sep 26, 2007·Expert Review of Molecular Diagnostics·Evan Y Yu, David A Mankoff
Nov 1, 2007·Expert Opinion on Investigational Drugs·Steven J KridelCharles W Pemble
Mar 2, 2016·Proteomics. Clinical Applications·Heng ZhaoMu Wang
May 5, 2010·Pathology·George J Netto, Jonathan I Epstein
Mar 10, 2009·Medicina clínica·Teresa PuigRamon Colomer
Jun 17, 2008·The Journal of Urology·Akio HoriguchiMasamichi Hayakawa
May 1, 2008·Diagnostic Histopathology·Elisa BenedettiniMassimo Loda
Dec 23, 2003·Journal of Cellular Biochemistry·Antonella BaronMassimo Loda
Sep 5, 2008·International Journal of Cancer. Journal International Du Cancer·Marco A CarvalhoEdgard Graner
Oct 20, 2006·Statistical Applications in Genetics and Molecular Biology·Robert P DeCondeRuth Etzioni
Apr 16, 2008·British Journal of Haematology·Yutaka OkawaKenneth C Anderson
May 25, 2010·Cancer Science·Soichiro MurataNobuhiro Ohkohchi
Apr 30, 2005·The Journal of Steroid Biochemistry and Molecular Biology·P TuohimaaY-R Lou
Jan 25, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Johannes V SwinnenGuido Verhoeven

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