Increased fecal calprotectin levels in Crohn's disease correlate with elevated serum Th1- and Th17-associated cytokines

PloS One
Arno R BourgonjeGerard Dijkstra

Abstract

Patient-reported symptoms and endoscopic disease activity do not correlate well in Crohn's disease (CD). This warrants the need for reliable biomarkers to early detect active intestinal inflammation. Currently, the fecal calprotectin level is the most commonly used biomarker for inflammatory activity in CD. However, the diagnostic accuracy of the fecal calprotectin level is not fully efficacious and diagnosis may be further improved by the identification of other biomarkers for active CD. Here, we studied the association of a variety of serum disease markers with fecal calprotectin levels in CD patients. 39 CD patients were included and subdivided into 'normal' (defined as < 200 mg/kg feces) and 'increased' (defined as > 200 mg/kg feces) fecal calprotectin level groups. Serum levels of 37 different cytokines, chemokines and markers for angiogenesis and vascular injury were quantified by an electrochemiluminescence multiplex assay (V-PLEX Human Biomarker 40-Plex Kit of Meso Scale Discovery ®). Correlations between individual biomarkers and the fecal calprotectin level were assessed using Spearman's correlation coefficient (ρ). A highly significant positive correlation was observed between the pro-inflammatory serum cytokines IFN...Continue Reading

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Citations

Mar 20, 2019·Autoimmunity·Murillo Duarte-SilvaCristina Ribeiro de Barros Cardoso
Dec 25, 2019·Journal of Crohn's & Colitis·Julius Z H von MartelsGerard Dijkstra
Apr 7, 2019·Archives of Gynecology and Obstetrics·Günther A RezniczekClemens B Tempfer
May 14, 2019·Frontiers in Physiology·Arno R BourgonjeHarry van Goor
Sep 8, 2021·Journal of Crohn's & Colitis·Arno R BourgonjeRinse K Weersma

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Software Mentioned

SPSS Statistics
MSD Discovery Workbench

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