Increased fetal heart rate variability in periventricular leukomalacia

Brain & Development
Hirokazu KurahashiKazuyoshi Watanabe

Abstract

This study used quantitative analysis to determine whether increased variability in fetal heart rate (FHR) is related to the risk of developing periventricular leukomalacia (PVL). We analyzed 124 FHR traces of neonates delivered preterm at 27-33 weeks' gestation to 105 mothers. FHR traces 1-3h before delivery were translated into power-spectrum curves using a fast Fourier transformation. The total power (the area under the curve of 1-10 cycles per minute), segmental power of every cycle per minute, peak power, and frequency edges were calculated, and their relationship with the subsequent development of PVL was examined. Total power was significantly higher in the PVL group (n=9, median 1813, range 1064-2426) compared to the non-PVL group (n=114, median 1383, range 381-3324, p=0.029). Infants in the PVL group had greater segmental power in segments with 1-2, 2-3, and 9-10 cycles per minute, than those in the non-PVL group. Total power of ⩾1550 was significantly correlated with the subsequent development of PVL and premature rupture of membranes. Furthermore, the frequency of pregnancy-induced hypertension was significantly reduced in the fetuses with a total power of ⩾1550. Our study suggests that a fetus with increased FHR var...Continue Reading

References

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Aug 10, 2010·Annals of Neurology·Chang-Yi LinChao-Ching Huang
Aug 28, 2013·Brain & Development·Takeshi TsujiKazuyoshi Watanabe

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Citations

Nov 15, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Anna Gracia-Perez-BonfilsEdwin Chandraharan
Jan 5, 2021·Developmental Neuropsychology·Vania Aldrete-CortezAdrián Poblano

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