Increased fluidity and oxidation of malarial lipoproteins: relation with severity and induction of endothelial expression of adhesion molecules

Lipids in Health and Disease
Nathawut SibmoohRachanee Udomsangpetch

Abstract

Oxidative stress has been demonstrated in malaria. The potential oxidative modification of lipoproteins derived from malaria patients was studied. These oxidized lipids may have role in pathogenesis of malaria. The plasma lipid profile and existence of oxidized forms of very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) were investigated in malaria (17 mild and 24 severe patients) and 37 control subjects. Thiobarbituric acid reactive substances (TBARs), conjugated dienes, tryptophan fluorescence and fluidity of lipoproteins were determined as markers of oxidation. The biological effect of malarial lipoproteins was assessed by the expression of adhesion molecules on endothelial cells. Malarial lipoproteins had decreased cholesterol (except in VLDL) and phospholipid. The triglyceride levels were unchanged. The cholesterol/phospholipid ratio of LDL was decreased in malaria, but increased in VLDL and HDL. TBARs and conjugate dienes were increased in malarial lipoproteins, while the tryptophan fluorescence was decreased. The fluidity of lipoproteins was increased in malaria. These indicated the presence of oxidized lipoproteins in malaria by which the degree of oxidation was correla...Continue Reading

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Citations

Apr 7, 2017·Canadian Journal of Physiology and Pharmacology·Paméla CamponovaAbdelouahed Khalil
Oct 10, 2006·Biochemical and Biophysical Research Communications·Noppawan Phumala MoralesUdom Chantharaksri
Apr 2, 2013·Journal of Lipid Research·Anatol KontushM John Chapman
Apr 1, 2015·Infection and Immunity·Carole GuillaumeChristiane Deregnaucourt
Jan 5, 2017·Journal of Tropical Medicine·Rosa Maria DiasMarcieni Ataíde de Andrade
Feb 4, 2021·Parasitology Research·Sana AqeelWajihullah Khan
Mar 23, 2021·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·A O AbdulkareemU S Ugbomoiko

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Methods Mentioned

BETA
blood drawing

Software Mentioned

StatView

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