Increased fluoroquinolone resistance with time in Escherichia coli from >17,000 patients at a large county hospital as a function of culture site, age, sex, and location

BMC Infectious Diseases
Lauren Becnel BoydLynn Zechiedrich

Abstract

Escherichia coli infections are common and often treated with fluoroquinolones. Fluoroquinolone resistance is of worldwide importance and is monitored by national and international surveillance networks. In this study, we analyzed the effects of time, culture site, and patient age, sex, and location on fluoroquinolone resistance in E. coli clinical isolates. To understand how patient factors and time influenced fluoroquinolone resistance and to determine how well data from surveillance networks predict trends at Ben Taub General Hospital in Houston, TX, we used Perl to parse and MySQL to house data from antibiograms (n congruent with 21,000) for E. coli isolated between 1999 to 2004 using Chi Square, Bonferroni, and Multiple Linear Regression methods. Fluoroquinolone resistance (i) increased with time; (ii) exceeded national averages by 2- to 4-fold; (iii) was higher in males than females, largely because of urinary isolates from male outpatients; (iv) increased with patient age; (v) was 3% in pediatric patients; (vi) was higher in hospitalized patients than outpatients; (vii) was higher in sputum samples, particularly from inpatients, than all other culture sites, including blood and urine, regardless of patient location; and ...Continue Reading

References

Mar 22, 1995·JAMA : the Journal of the American Medical Association·S SaintD Grady
Jun 19, 2001·Diagnostic Microbiology and Infectious Disease·R N JonesUNKNOWN SENTRY Antimicrobial Surveillance Program Participants Group (USA)
Jul 5, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S K FridkinUNKNOWN National Nosocomial Infections Surveillance (NNIS) System Hospitals
Feb 18, 2003·JAMA : the Journal of the American Medical Association·Melinda M NeuhauserJohn P Quinn
Jul 16, 2003·Current Opinion in Infectious Diseases·Rafael CantónFernando Baquero
Dec 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marcus J ZervosTeresa J Lubowski
Jul 31, 2004·Annals of Clinical Microbiology and Antimicrobials·Mark E JonesRichard P Wenzel
Oct 30, 2004·Scandinavian Journal of Infectious Diseases·Ulf RiedePeter E Ochsner
Dec 22, 2004·Current Infectious Disease Reports·F M E Wagenlehner, K G Naber
Feb 18, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J-I AlósJ Perianes
Mar 5, 2005·The American Journal of Medicine·Jeffrey A LinderRandall S Stafford
Apr 26, 2005·International Journal of Antimicrobial Agents·Katie L HopkinsE John Threlfall
Jun 9, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·George A Jacoby
Jun 16, 2005·The Journal of Antimicrobial Chemotherapy·Stephen H GillespieTimothy D McHugh
Jun 21, 2005·Emerging Infectious Diseases·John M StellingStuart B Levy
Dec 2, 2005·Emerging Infectious Diseases·Elizabeth L HannahMatthew H Samore
Sep 5, 2006·Pediatrics·UNKNOWN Committee on Infectious Diseases
Sep 29, 2006·Antimicrobial Agents and Chemotherapy·Xuan QinPhillip I Tarr
Sep 30, 2006·The Lancet Infectious Diseases·Ari RobicsekDavid C Hooper

❮ Previous
Next ❯

Citations

Feb 25, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M KreskenUNKNOWN Study Group
Aug 2, 2012·Quarterly Reviews of Biophysics·Jonathan M FoggLynn Zechiedrich
Jul 11, 2009·The Journal of Antimicrobial Chemotherapy·Renu SinghVincent H Tam
Apr 7, 2010·The Journal of Antimicrobial Chemotherapy·Ulrich S JensenUNKNOWN DANRES study group
May 18, 2013·Nucleic Acids Research·Kevin M JudeJames M Berger
May 31, 2012·TheScientificWorldJournal·Rustom P ManeckshaJohn A Thornhill
Oct 8, 2008·Antimicrobial Agents and Chemotherapy·Sonia K Morgan-LinnellLynn Zechiedrich
Jan 12, 2011·Antimicrobial Agents and Chemotherapy·José Miguel Sahuquillo-ArceHermelinda Vanaclocha
Mar 1, 2011·BMC Microbiology·Sreela S NamboodiriIruka N Okeke
Aug 31, 2012·Emerging Infectious Diseases·Allen C ChengThomas Gottlieb
Feb 24, 2016·Frontiers in Microbiology·Alexandra BaduraAndrea J Grisold
Aug 2, 2011·The American Journal of Emergency Medicine·Shannon E MoffettRalph Gonzales
Apr 5, 2011·Trends in Pharmacological Sciences·Kathleen E MachJoseph C Liao
Feb 8, 2013·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Nikolay P BraykovRamanan Laxminarayan
Apr 11, 2014·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Mi-Sun HaWoon-Seok Yeo
May 6, 2015·Antimicrobial Resistance and Infection Control·Shamshul AnsariMoti Lal Chapagain
Mar 2, 2017·Nature Reviews. Urology·Michael DavenportJoseph C Liao
Jun 18, 2009·Chemical Communications : Chem Comm·Warren R J D GallowayDavid R Spring
Nov 9, 2017·Journal of Medical Microbiology·Alexander GarciaPayman Nasr
May 27, 2021·Drugs·Dirk VogelaersUNKNOWN Abdominal Sepsis Study (‘AbSeS’) Group on behalf of the Trials Group of the European Society of Intensive Care Medicine

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Software Mentioned

Perl
MySQL
Dade MicroScan
SPSS

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