Increased fractional anisotropy in the motor tracts of Parkinson's disease suggests compensatory neuroplasticity or selective neurodegeneration

European Radiology
Jilu Princy MoleDavid E J Linden

Abstract

To determine the differences in motor pathways and selected non-motor pathways of the basal ganglia in Parkinson's disease (PD) patients compared to healthy controls (HCs). We analysed diffusion weighted imaging data of 24 PD patients and 26 HCs. We performed deterministic tractography analysis using the spherical deconvolution-based damped Richardson-Lucy algorithm and subcortical volume analysis. We found significantly increased fractional anisotropy (FA) in the motor pathways of PD patients: the bilateral corticospinal tract (right; corrected p = 0.0003, left; corrected p = 0.03), bilateral thalamus-motor cortex tract (right; corrected p = 0.02, left; corrected p = 0.004) and the right supplementary area-putamen tract (corrected p = 0.001). We also found significantly decreased FA in the right uncinate fasiculus (corrected p = 0.01) and no differences of FA in the bilateral supero-lateral medial forebrain bundles (p > 0.05) of PD patients compared to HCs. There were no subcortical volume differences (p > 0.05) between the PD patients and HCs. These results can inform biological models of neurodegeneration and neuroplasticity in PD. We suggest that increased FA values in the motor tracts in PD may reflect compensatory reorgan...Continue Reading

References

Mar 1, 1994·Journal of Magnetic Resonance. Series B·P J BasserD LeBihan
Apr 12, 2003·Trends in Neurosciences·Erwan BezardJonathan M Brotchie
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Nov 2, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Heiko BraakKelly Del Tredici
Oct 22, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Yaniv Assaf
Mar 26, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alexander Leemans, Derek K Jones
Jul 23, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ofer PasternakYaniv Assaf
Feb 11, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ives R LevesqueG Bruce Pike
Mar 1, 2011·NeuroImage·Brian PatenaudeMark Jenkinson
Sep 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Claudia Metzler-BaddeleyMichael J O'Sullivan
May 8, 2013·Brain : a Journal of Neurology·Rebecca J Von Der HeideIngrid R Olson
Jul 23, 2013·Journal of the Neurological Sciences·Frederick J A MeijerBozena Goraj
Oct 12, 2013·Neuroscience and Biobehavioral Reviews·David Lindenbach, Christopher Bishop
Apr 8, 2014·Cerebral Cortex·O PhillipsM Di Paola
Apr 18, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Francesco VerganiFlavio Dell'Acqua
Apr 18, 2015·Brain : a Journal of Neurology·Damian M HerzHartwig R Siebner

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Citations

May 26, 2017·Current Opinion in Neurology·Sarah GregoryGeraint Rees
Oct 4, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Roxana G Burciu, David E Vaillancourt
Mar 21, 2019·Human Brain Mapping·Ilona LippValentina Tomassini
Aug 20, 2019·PloS One·Bethany R IsaacsMax C Keuken
Dec 7, 2018·Neurology·Meher R JuttukondaDaniel O Claassen
Jan 12, 2020·Human Brain Mapping·Francois RheaultMaxime Descoteaux
Jan 9, 2019·Brain Imaging and Behavior·Zehra Çakmak ÇelikZeki Yüncü
Jun 20, 2019·Frontiers in Aging Neuroscience·Laura PelizzariFrancesca Baglio
Feb 9, 2017·Journal of Neurology·Farzaneh Rahmani, Mohammad Hadi Aarabi
Dec 15, 2020·Lupus·Maria Del C Valdés HernándezStewart J Wiseman
Jul 10, 2019·Clinical Imaging·Yildizhan SengulElan D Louis
Dec 27, 2019·NeuroImage·Ilona LippDerek K Jones
May 14, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jakob WasserthalDusan Hirjak
May 22, 2021·Parkinsonism & Related Disorders·Jakub SurkontFang Ba
Jun 27, 2021·NPJ Parkinson's Disease·Christina AndicaShigeki Aoki
Jul 22, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Renata RozovskyMary L Phillips
Aug 25, 2021·Brain Imaging and Behavior·Masoumeh RostampourMojtaba Zarei

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Methods Mentioned

BETA
dissection

Clinical Trials Mentioned

NCT01867827

Software Mentioned

ExploreDTIv4
ExploreDTI
R
SIENAX ( Structural Image Evaluation using Normalization of At...
FSL
AxCaliber
FIRST ( FMRIB Image Registration and Segmentation Tool )
CHARMED

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