Increased Fracture Risk with Furosemide Use in Children with Congenital Heart Disease

The Journal of Pediatrics
Ji Haeng HeoBrady S Moffett

Abstract

To determine the association of furosemide therapy with the incidence of bone fractures in children with congenital heart disease. We conducted a retrospective cohort study with data extracted from the 2008-2014 Texas Medicaid databases. Pediatric patients aged <12 years diagnosed with congenital heart disease, cardiomyopathy, or heart failure were included. Patients taking furosemide were categorized into a furosemide-adherent group (medication possession ratio of ≥70%), and a furosemide-nonadherent group (medication possession ratio of <70%). A third group of patients was matched to the furosemide user groups by using propensity score matching. A multivariate logistic regression and Cox proportional hazard model with a Kaplan-Meier plot (time-to-fracture) were used to compare the 3 groups, controlling for baseline demographics and clinical characteristics. After matching, 3912 patients (furosemide adherent, n = 254; furosemide nonadherent, n = 724; no furosemide, n = 2934) were identified. The incidence of fractures was highest for the furosemide-adherent group (9.1%; 23 of 254), followed by the furosemide-nonadherent group (7.2%; 52 of 724), which were both higher than for patients who did not receive furosemide (5.0%; 148 o...Continue Reading

Citations

Mar 27, 2020·International Journal of Environmental Research and Public Health·Brandon ChuaKai Zhen Yap
Jan 23, 2020·Pediatric Research·Jonathan MichaudNathalie Auger
May 2, 2021·NeoReviews·Snigdha BhatiaSunil K Jain

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