PMID: 7520982Sep 1, 1994Paper

Increased frequencies of micronuclei in early spermatids of rats following exposure of young primary spermatocytes to acrylamide

Mutation Research
Y Xiao, A D Tates

Abstract

The 'suspension method' for detection of micronuclei in early spermatids (Golgi phase 1 + 2) of rats was used to study induction of chromosomal damage in spermatocytes exposed to single (50 and 100 mg/kg) or fractionated (4 x 50 mg/kg; 24-h intervals) doses of acrylamide. Animals were killed at different time intervals after treatment to measure induction of damage in different stages of spermatocyte development. A statistically significant enhancement of micronucleus frequencies was found after exposure of pre-leptotene spermatocytes to a single dose of 100 mg/kg (days 18 and 20 after treatment) or a fractionated dose of 4 x 50 mg/kg (day 19). In the latter case there was also a significant effect in zygotene spermatocytes that were sampled 15 days after treatment. Comparative studies indicated that the original 'suspension method' can be simplified by omitting enzyme treatments for the release of germ cells from the seminiferous tubules. In the present acrylamide study the old and new procedures gave similar results.

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Citations

Aug 1, 1995·Mutation Research·K L DearfieldD J Brusick
Jun 12, 1996·Mutation Research·I D AdlerA D Tates
Sep 23, 1996·Mutation Research·D M SalvadoriA T Natarajan
Dec 13, 2000·Mutation Research·A Russo
Mar 29, 2011·Mutagenesis·Naoki KoyamaMasamitsu Honma
Mar 9, 2010·Environmental and Molecular Mutagenesis·Naoki KoyamaMasamitsu Honma
Feb 25, 2005·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Jeanne MansonPeter Working
Sep 16, 2006·Critical Reviews in Toxicology·A ShippC Van Landingham
Feb 9, 2019·Central Nervous System Agents in Medicinal Chemistry·Shinomol George KunnelFarhan Zameer
Feb 19, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Soichiro HagioKenichi Masumura
Mar 30, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gye-Hyeong WooMasao Hirose

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