Increased frequency of CD27- (naive) B cells and their phenotypic alteration in HIV type 1-infected patients

AIDS Research and Human Retroviruses
Yong ChongJun Hayashi

Abstract

To investigate HIV-1-related B cell disorders, the quantity of peripheral CD27 negative (CD27-) B cells, their CD38, CD95, and bcl-2 intensities, and their apoptosis susceptibility were examined by flow cytometry analysis in 16 drug-naive patients, 27 HAART-treated patients, and 20 uninfected controls. CD27- B cells have been recognized as naive B cells. The mean percentage of CD27- B cells was significantly higher in drugnaive patients (88.1%) and in HAART-treated patients (83.9%) than in controls (68.6%) (p < 0.01). The intensities of CD38 and CD95 on CD27- B cells were significantly higher in drug-naive patients than in controls (p < 0.01). The intensity of CD95 on CD27- B cells in HAART-treated patients was lower than that of drug-naive patients, but significantly higher than that of controls (p < 0.01). The intensity of bcl-2 on CD27- B cells in drug-naive patients was lower than that of controls. In drug-naive patients, CD27-B cells with high CD38 expression represented low bcl-2 expression. The CD27- B cells of drug-naive patients showed an increased susceptibility to apoptosis, characterized by diminished cell size and a high frequency of annexin-V binding, compared with controls and HAART-treated patients. These findin...Continue Reading

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Feb 5, 2008·The Journal of Infectious Diseases·Susan MoirAnthony S Fauci
Aug 20, 2010·AIDS Research and Human Retroviruses·Madeleine BundersMarie-Louise Newell
Oct 8, 2005·Clinical and Diagnostic Laboratory Immunology·Krishanthi SubramaniamLiise-Anne Pirofski
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