Increased frequency of circulating follicular helper T cells in lupus patients is associated with autoantibody production in a CD40L-dependent manner

Cellular Immunology
Huaheng XuJie Pang

Abstract

This study was to determine the frequency of circulating follicular helper T (Tfh) cells in patients with systemic lupus erythematosus (SLE) and investigate the relationship between Tfh cells and autoantibody production. An increased frequency of circulating Tfh cells was found in SLE patients, and there were positive co-relationship between Tfh cells and SLEDAI, serum IgG, Anti-nuclear antibody titers and anti-dsDNA (P=0.0004, 0.0006, 0.0237, 0.0000, respectively). B cells sorted from SLE patients produced more IgG than healthy controls in the presence of autologous CD4(+) T cells. CD4(+) T cells were further sorted into CXCR5(+) and CXCR5(-) cells, and CD4(+)CXCR5(+) T cells helped B cells producing more IgG than CD4(+)CXCR5(-) T cells. Blocking the interaction of T cells and B cells by anti-CD40L but not anti-ICOSL dramatically decreased antibody production in the co-culture system. This study suggests that increased frequency of circulating Tfh cells in SLE patients is associated with excess B-cell help and autoantibody production in a CD40L dependent manner.

References

Dec 1, 1987·Clinical Immunology and Immunopathology·B S EdwardsC L Hoffman
Feb 22, 2005·Immunology·Sanjeev KumarDavid A Isenberg
Feb 18, 2009·The Journal of Experimental Medicine·Michelle A LintermanCarola G Vinuesa
Apr 17, 2012·Immunological Reviews·Jason S WeinsteinJoe Craft
Jun 1, 2012·Clinical & Developmental Immunology·Jie MaShengjun Wang
Aug 4, 2012·The Journal of Rheumatology·Benjamin TerrierPatrice Cacoub
Sep 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xijun OuKong-Peng Lam
Feb 15, 2013·Immunological Reviews·Roybel R Ramiscal, Carola G Vinuesa
Mar 29, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Marianne Frieri
Aug 10, 2013·Journal of the American Society of Nephrology : JASN·Maciej Lech, Hans-Joachim Anders

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Citations

Dec 31, 2015·International Immunology·Yangyang ZhuYun-Cai Liu
Nov 14, 2015·Science China. Life Sciences·LiDan ZhaoXuan Zhang
Sep 17, 2016·Current Opinion in Immunology·Abel Suárez-FueyoGeorge C Tsokos
Jul 28, 2017·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Takashi Maehara
Mar 2, 2018·Scandinavian Journal of Clinical and Laboratory Investigation·Defeng ZhangGengyun Sun
May 11, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristen M ValentineKatrina K Hoyer
Apr 17, 2018·Arthritis & Rheumatology·Ye Ji LeeEun Bong Lee
Jun 18, 2020·Immunological Medicine·Izumi KurataTakayuki Sumida
Apr 5, 2017·Rheumatology·Olga ZharkovaLaurie S Davis
Jul 6, 2019·Frontiers in Immunology·Kristen M Valentine, Katrina K Hoyer
Jun 18, 2017·Frontiers in Immunology·Gretchen N de GraavCarla C Baan
Mar 20, 2020·The Journal of Clinical Investigation·Zijun WangQianjin Lu
Aug 2, 2018·Frontiers in Immunology·Noémie GensousChristophe Richez
Mar 26, 2021·Journal of Immunology Research·Yolanda P Alemán-GarcíaAdriana K Chávez-Rueda
Apr 19, 2021·Journal of Leukocyte Biology·Andrew P Hart, Terri M Laufer
Jul 10, 2021·Clinical and Experimental Immunology·Izumi KurataIsao Matsumoto
Sep 2, 2021·Expert Review of Clinical Immunology·Shingo Nakayamada, Yoshiya Tanaka
Dec 12, 2017·Best Practice & Research. Clinical Rheumatology·Thomas Rose, Thomas Dörner

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