Increased frequency of rapid acetylator genotypes in patients with brain astrocytoma and meningioma

Acta Neurologica Scandinavica
M OliveraJ A G Agúndez

Abstract

The arylamine N-acetyltransferase (NAT2) is a polymorphic enzyme involved in deactivation and activation of carcinogens through N- and O-acetylation. We investigated the association between the genetic NAT2 polymorphism and brain tumors by analysis of genomic DNA from 71 brain tumor patients and 258 healthy controls. Seven single nucleotide polymorphisms of the NAT2 gene were studied by using allele-specific polymerase chain reaction amplification. Ten different NAT2 allelic variants were identified in both patient and control groups. A higher number of individuals carrying functional NAT2 genes, and therefore with a rapid acetylation phenotype, was found in brain tumor patients vs healthy volunteers (OR 1.79, 95% CI 1.05-3.05; P < 0.05). This is observed either for patients suffering from meningioma or astrocytoma, and this is due to an increase of the wild-type NAT2*4 allelic variant frequency (OR 1.48, 95% CI 0.99-2.19), and a reduction of the commonest defective allelic variant NAT2*5B in the brain tumor patients, compared with healthy subjects (OR 0.54, 95% CI 0.37-0.80). This observation indicates that NAT2 could be considered as a low-penetrance gene for brain tumors, and that individuals carrying rapid acetylation allel...Continue Reading

References

Feb 1, 1994·The Biochemical Journal·D HickmanE Sim
Aug 1, 1995·Pharmacogenetics·C MartínezJ Benítez
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·U A Meyer, U M Zanger
Jun 8, 2004·Current Drug Metabolism·Jose A G Agundez

❮ Previous
Next ❯

Citations

Feb 14, 2008·Journal of the National Cancer Institute·Lara BethkeRichard Houlston
Aug 5, 2010·Archives of Medical Research·Malika KhelilBouchentouf Tayebi
May 2, 2015·Brain Tumor Pathology·Mario VenzaIsabella Venza
Jul 12, 2018·BioMed Research International·Recep Dursunİlknur Çınar
Dec 1, 2021·Journal of Neuro-oncology·Stephanie M RobertJennifer Moliterno

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.