Increased frontal functional networks in adult survivors of childhood brain tumors

NeuroImage. Clinical
Hongbo ChenHui Mao

Abstract

Childhood brain tumors and associated treatment have been shown to affect brain development and cognitive outcomes. Understanding the functional connectivity of brain many years after diagnosis and treatment may inform the development of interventions to improve the long-term outcomes of adult survivors of childhood brain tumors. This work investigated the frontal region functional connectivity of 16 adult survivors of childhood cerebellar tumors after an average of 14.9 years from diagnosis and 16 demographically-matched controls using resting state functional MRI (rs-fMRI). Independent component analysis (ICA) was applied to identify the resting state activity from rs-fMRI data and to select the specific regions associated with executive functions, followed by the secondary analysis of the functional networks connecting these regions. It was found that survivors exhibited differences in the functional connectivity in executive control network (ECN), default mode network (DMN) and salience network (SN) compared to demographically-matched controls. More specifically, the number of functional connectivity observed in the survivors is higher than that in the controls, and with increased strength, or stronger correlation coefficie...Continue Reading

Citations

May 16, 2019·Journal of the International Neuropsychological Society : JINS·Tanya F PanwalaTricia Z King
Jan 13, 2017·PloS One·Hongbo Chen, Shaofeng Mo
Sep 29, 2017·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Tricia Z KingSchell M Hufstetler
Aug 25, 2018·Brain Connectivity·Michelle E Fox, Tricia Z King
Jan 14, 2020·NeuroImage. Clinical·Antonio Jimenez-MarinJesus M Cortes
Jan 31, 2021·Neuropsychology Review·Sarah V ClarkTricia Z King
Nov 19, 2020·Brain and Behavior·Janine S SpitzhüttlRegula Everts
Apr 23, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shelli R KeslerBrian J Nieman

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Methods Mentioned

BETA
imaging technique

Software Mentioned

SPM2
AlphaSim
REST REST )
REST
cogicat
REST Image Calculator Toolkit
Functional Connectivity Toolkit
BrainNet Viewer

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