Increased Functional MEG Connectivity as a Hallmark of MRI-Negative Focal and Generalized Epilepsy

Brain Topography
Yiwen Li HegnerNiels K Focke

Abstract

Epilepsy is one of the most prevalent neurological diseases with a high morbidity. Accumulating evidence has shown that epilepsy is an archetypical neural network disorder. Here we developed a non-invasive cortical functional connectivity analysis based on magnetoencephalography (MEG) to assess commonalities and differences in the network phenotype in different epilepsy syndromes (non-lesional/cryptogenic focal and idiopathic/genetic generalized epilepsy). Thirty-seven epilepsy patients with normal structural brain anatomy underwent a 30-min resting state MEG measurement with eyes closed. We only analyzed interictal epochs without epileptiform discharges. The imaginary part of coherency was calculated as an indicator of cortical functional connectivity in five classical frequency bands. This connectivity measure was computed between all sources on individually reconstructed cortical surfaces that were surface-aligned to a common template. In comparison to healthy controls, both focal and generalized epilepsy patients showed widespread increased functional connectivity in several frequency bands, demonstrating the potential of elevated functional connectivity as a common pathophysiological hallmark in different epilepsy types. F...Continue Reading

References

Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·J GrossR Salmelin
Jul 10, 2003·Lancet Neurology·Brian Litt, Javier Echauz
Dec 5, 2003·Cerebral Cortex·Bruce FischlAnders M Dale
Sep 8, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Guido NolteMark Hallett
Aug 11, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Jukka-Pekka OnnelaKimmo Kaski
May 23, 2007·Journal of Neuroscience Methods·Eric Maris, Robert Oostenveld
Jun 13, 2008·Epilepsy Research·Gaelle BettusFabrice Bartolomei
Feb 25, 2009·Human Brain Mapping·Jan-Mathijs Schoffelen, Joachim Gross
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Jan 5, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marie-Therese HorstmannKlaus Lehnertz
Apr 7, 2010·Physical Review Letters·M ChavezJ Martinerie
Apr 21, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S ArzyM Seeck
Jul 6, 2010·NeuroImage·Andrew ZaleskyEdward T Bullmore
Jan 22, 2011·Computational Intelligence and Neuroscience·Robert OostenveldJan-Mathijs Schoffelen
Mar 4, 2011·Epilepsia·Kost ElisevichSusan M Bowyer
Sep 29, 2011·NeuroImage·Ziad S Saad, Richard C Reynolds
Oct 7, 2011·Brain : a Journal of Neurology·Zhiqiang ZhangGuangming Lu
Jan 12, 2012·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Mark A Kramer, Sydney S Cash
Feb 15, 2013·Current Opinion in Neurology·Jerome EngelIstvan Mody
Sep 17, 2013·Epilepsia·Eric van DiessenCornelis J Stam
Feb 21, 2014·Seizure : the Journal of the British Epilepsy Association·Ting WuTianzi Jiang
Sep 30, 2014·Epilepsy Research·Woorim JeongChun Kee Chung
Dec 3, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Seung-Hyun JinChun Kee Chung
Mar 4, 2015·Current Opinion in Neurology·Joseph I Tracy, Gaelle E Doucet
May 20, 2015·Brain : a Journal of Neurology·Dario J EnglotSrikantan S Nagarajan
Jun 25, 2015·NeuroImage. Clinical·Guiomar NisoErnesto Pereda
Dec 9, 2015·Journal of Neuroscience Methods·Khalid HamandiKrish D Singh
Apr 10, 2016·Brain Topography·Mohammad-Reza Nazem-ZadehHamid Soltanian-Zadeh
May 15, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Eric van DiessenFloor E Jansen
Jun 16, 2016·Lancet Neurology·Asla PitkänenHeinz Beck

❮ Previous
Next ❯

Citations

Aug 6, 2019·Frontiers in Neurology·Pieter van MierloSerge Vulliemoz
Mar 7, 2020·Frontiers in Integrative Neuroscience·Arindam BhattacharjeeChristoph Braun
Nov 10, 2020·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Anto I BagićRichard C Burgess
Dec 3, 2020·Chaos·Leandro JungesJohn R Terry
Jul 11, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Matteo PesoliPierpaolo Sorrentino
Nov 28, 2021·Nature Reviews. Neurology·Bernd J VorderwülbeckeMartin Holtkamp

❮ Previous
Next ❯

Software Mentioned

SUMA
AFNI SUMA
FreeSurfer
imCoh
Brain Connectivity Toolbox
Matlab
Fieldtrip

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.