PMID: 8944571Oct 1, 1996Paper

Increased gall bladder volume in primary sclerosing cholangitis

Gut
P C van de MeebergG P VanBerge-Henegouwen

Abstract

The diagnosis of primary sclerosing cholangitis (PSC) requires invasive procedures such as liver biopsy and endoscopic retrograde cholangiography (ERC). Sonographic measurement of fasting gall bladder volume, which has been reported to be enlarged in PSC, could serve as a non-invasive screening test. Fasting gall bladder volume was studied in patients with PSC (n = 24), primary biliary cirrhosis (PBC, n = 13), liver cirrhosis due to other causes (n = 18), ulcerative colitis (n = 15), and healthy controls (n = 23). Meal induced gall bladder emptying was studied in patients with PSC, patients with PBC, and healthy controls. In patients with PSC gall bladder volume was greatly enlarged (72.9 (SEM 3.7) ml) compared with healthy controls (25.4 (1.7) ml, and patients with PBC (30.9 (2.7) ml), liver cirrhosis (31.3 (4.0) ml) or ulcerative colitis (25.8 (2.0) ml) (p < 0.0005 v all). In four patients with PSC the gall bladder wall was irregularly thickened (> 4 mm) as previously described in PSC. Postprandial residual fractions (% of fasting volume) were comparable between patients with PSC (17.5 (3.7)%) and those with PBC (23.6 (7.1%) and healthy controls (12.7 (2.3)%) Although gall bladder emptying seems normal, increased biliary pres...Continue Reading

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Citations

Jul 25, 2009·World Journal of Gastroenterology : WJG·Karouk SaidAnnika Bergquist
Jul 2, 2014·International Journal of Colorectal Disease·Rajkumar Cheluvappa
May 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Piero PortincasaDavid Q-H Wang
Jan 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roger ChapmanUNKNOWN American Association for the Study of Liver Diseases
Nov 28, 2006·Best Practice & Research. Clinical Gastroenterology·P PortincasaA Pezzolla
Nov 25, 2004·Clinics in Liver Disease·A Bergquist, U Broomé
Jan 29, 2008·Journal of Hepatology·Karouk SaidAnnika Bergquist
Jun 9, 2009·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver
Apr 2, 2013·Clinics in Liver Disease·Claudia O Zein
Dec 21, 2004·World Journal of Gastroenterology : WJG·Piero PortincasaGerard P van Berge-Henegouwen
May 31, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christoph SchrammUNKNOWN MRI working group of the IPSCSG
Jul 6, 2021·Journal of Magnetic Resonance Imaging : JMRI·Lorenz PflegerMartin Krššák

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