Increased glia density in the caudate nucleus in williams syndrome: Implications for frontostriatal dysfunction in autism

Developmental Neurobiology
Kari L HansonKaterina Semendeferi

Abstract

Williams syndrome (WS) is a rare neurodevelopmental disorder with a well-described, known genetic etiology. In contrast to Autism Spectrum Disorders (ASD), WS has a unique phenotype characterized by global reductions in IQ and visuospatial ability, with relatively preserved language function, enhanced reactivity to social stimuli and music, and an unusual eagerness to interact socially with strangers. A duplication of the deleted region in WS has been implicated in a subset of ASD cases, defining a spectrum of genetic and behavioral variation at this locus defined by these opposite extremes in social behavior. The hypersociability characteristic of WS may be linked to abnormalities of frontostriatal circuitry that manifest as deficits in inhibitory control of behavior. Here, we examined the density of neurons and glia in associative and limbic territories of the striatum including the caudate, putamen, and nucleus accumbens regions in Nissl stained sections in five pairs of age, sex, and hemisphere-matched WS and typically-developing control (TD) subjects. In contrast to what is reported in ASD, no significant increase in overall neuron density was observed in this study. However, we found a significant increase in the density ...Continue Reading

References

Jan 1, 1990·American Journal of Medical Genetics. Supplement·O Udwin, W Yule
Feb 19, 1996·The Journal of Comparative Neurology·G E MeredithS N Haber
Aug 1, 1996·Neuroscience Research·A ParentF Cicchetti
Jul 21, 1997·The Journal of Comparative Neurology·D J HoltC B Saper
May 27, 1997·Neuroreport·J AtkinsonF Braddick
Aug 23, 2000·Journal of Cognitive Neuroscience·W JonesR Adolphs
Aug 23, 2000·Journal of Cognitive Neuroscience·A L ReissU Bellugi
Aug 23, 2000·Journal of Cognitive Neuroscience·A M Galaburda, U Bellugi
Nov 18, 2000·Journal of Neurology·K NakanoH Ushiro
Mar 29, 2001·Physiological Reviews·N Baumann, D Pham-Dinh
Jun 29, 2002·Journal of Child Neurology·Petter StrømmeKjersti Ramstad
Sep 12, 2002·Archives of Neurology·Albert M GalaburdaGordon F Sherman
Jan 1, 2003·NeuroImage·Daniel J LevitinAllan L Reiss
Mar 18, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Helen Tager-Flusberg, Robert M Joseph
Dec 1, 1961·Circulation·J C WILLIAMSJ B LOWE
Jan 7, 2004·American Journal of Medical Genetics. Part a·Teresa F DoyleJohn Graham
Jan 20, 2004·Journal of Chemical Neuroanatomy·Suzanne N Haber
Mar 12, 2004·Biological Psychiatry·Massihullah HamidiJoseph L Price
Apr 9, 2004·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Caroline E PhillipsAnnette Karmiloff-Smith
May 28, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Allan L ReissAl Galaburda
Jan 12, 2005·Neurology·M A EckertA L Reiss
Feb 26, 2005·Pediatric Neurology·Ximena CarrascoFrancisco Aboitiz
Mar 22, 2005·Brain Research·Dorothy P HolingerAlbert M Galaburda
Jun 9, 2005·Biological Psychiatry·Eric HollanderMonte Buchsbaum
Jul 12, 2005·Neuropsychologia·Elisa FrigerioRenato Borgatti
Jul 12, 2005·Nature Neuroscience·Andreas Meyer-LindenbergKaren Faith Berman
Jan 3, 2006·Nature Neuroscience·Nicoletta KessarisWilliam D Richardson
Jun 9, 2006·Nature Reviews. Neuroscience·Andreas Meyer-LindenbergKaren Faith Berman
Jul 5, 2006·Acta Neuropathologica·Manuel F CasanovaChristoph Schmitz
Jul 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cynthia Mills Schumann, David G Amaral
Aug 11, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Suzanne N HaberRoberta Calzavara
Aug 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Chet C SherwoodPatrick R Hof
Sep 16, 2006·Neuropathology and Applied Neurobiology·D P BuxhoevedenE Courchesne
Sep 26, 2006·Biological Psychiatry·Dean MobbsAllan L Reiss
Oct 27, 2006·Journal of Autism and Developmental Disorders·Shawn E ChristLeonard Green
Jan 17, 2007·Biological Psychiatry·Marieke LangenHerman van Engeland
Jan 24, 2007·Development and Psychopathology·Jon Brock
Feb 17, 2007·Brain : a Journal of Neurology·Pawel KreczmanskiChristoph Schmitz
Feb 28, 2007·Mental Retardation and Developmental Disabilities Research Reviews·Carolyn B Mervis, Angela M Becerra
Mar 9, 2007·Annals of the New York Academy of Sciences·Mauricio R Delgado
Mar 17, 2007·Science·Jonathan SebatMichael Wigler
Jun 5, 2007·Neurobiology of Aging·D P PelvigB Pakkenberg
Aug 2, 2007·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Jonathan S BergSau Wai Cheung
Aug 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bernard W BalleineOkihide Hikosaka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Autism: Treatment Targets

The absence of effective treatments for autism are due to the high clinical and genetic heterogeneity between affected individuals, restricted knowledge of the underlying pathophysiological mechanisms, and the lack of reliable diagnostic biomarkers. Identification of more homogenous biological subgroups is therefore essential for the development of novel treatments based on the molecular mechanisms underpinning autism and autism spectrum disorders. Find the latest research on autism treatment targets here.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Related Papers

Journal of the American Academy of Child and Adolescent Psychiatry
Alan LincolnCatherine Lord
Autism Research : Official Journal of the International Society for Autism Research
Caroline Horton LewKaterina Semendeferi
© 2022 Meta ULC. All rights reserved