Increased glomerular and interstitial LFA-1 expression in proteinuric immunoglobulin A nephropathy

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
E AlexopoulosM Papadimitriou

Abstract

The cell populations infiltrating the kidneys and the LFA-1 expression were studied in renal biopsy specimens from patients with proteinuric (n = 15, group 1) and non-proteinuric (n = 12, group 2) immunoglobulin A nephropathy. Both groups were matched for age and renal function at the time of biopsy. Proliferative glomerular changes were more commonly see in group 1. Both groups had similar numbers of intraglomerular and interstitial total leukocytes, monocytes/macrophages, and T cells (P = NS). However, glomerular LFA-1 alpha- and -beta-positive cells were significantly higher in group 1 (2.3 +/- 0.2 and 3.3 +/- 0.1 per glomerulus) than in group 2 (0.2 +/- 0.08 and 0.5 +/- 0.05 per glomerulus) (P < 0.005 and P < 0.01, respectively). Group 1 had much higher interstitial LFA-1 alpha- (109 +/- 20/mm(2)) and -beta-positive cells (157 +/- 40/mm(2)) in comparison with group 2 (29 +/- 12/mm(2) and 42 +/- 17/mm(2)). (P < 0.005 and P < 0.01, respectively). No association between glomerular and interstitial LFA-1-positive cells was seen. In addition, tubular HLA-DR expression was higher in group 1 (29 +/- 6/mm(2)) than in group 2 (9 +/- 2/mm(2)) (P < 0.005), but the interstitial HLA-DR-positive cells were similar in both groups. There w...Continue Reading

References

Jul 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K A Nath
Aug 1, 1991·Kidney International·W H Baricos, S V Shah
Jul 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E AlamartineF Berthoux
Dec 1, 1989·Kidney International·G A Bishop, B M Hall
Jan 1, 1989·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E AlexopoulosJ S Cameron
May 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E AlexopoulosJ S Cameron
Oct 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E SabadiniG D'Amico
Mar 1, 1988·Kidney International·K NeelakantappaD S Baldwin
Apr 1, 1987·Kidney International·D H HookeR C Atkins
Jul 1, 1981·Clinical Immunology and Immunopathology·P G NataliS Ferrone
Feb 1, 1993·The Journal of Clinical Investigation·M S MulliganP A Ward
Jan 1, 1994·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E AlexopoulosM Papadimitriou
Jan 1, 1994·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A C Ong, L G Fine
Mar 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S N Emancipator
Feb 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A C Ong, L G Fine
May 1, 1993·Journal of the American Society of Nephrology : JASN·H Y LanR C Atkins
Mar 1, 1993·Immunology Today·C R Mackay, B A Imhof

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Citations

Dec 17, 2003·Kidney International·Efstathios Alexopoulos
Aug 4, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M HeinzelmannJ C Passmore

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