PMID: 3751499Jun 1, 1986Paper

Increased glutathione peroxidase activity in erythrocytes in patients with Alzheimer's disease/senile dementia of Alzheimer's type

Acta Neurologica Scandinavica
G AnnerénT Lundin

Abstract

Glutathione peroxidase (GSH-Px) activity in erythrocytes was studied in 9 patients with Alzheimer's disease/senile dementia of Alzheimer's type (AD/SDAT) of ages 34-64 years and compared with that in 16 healthy controls of ages 21-66 years. The median GSH-Px activity in erythrocytes from AD/SDAT patients was 408, mu kat/1 (range 338-500 mu kat/1) and that from healthy controls 348, mu kat/1 (range 258-439 mu kat). This difference was significant (p less than 0.005) Wilcoxon rank test. Since there are great clinical and pathological similarities between AD/SDAT and the dementia of Down's syndrome (DS) patients and since both these groups of patients have increased activity of the selenium-dependent enzyme GSH-Px, it is suggested that there could be a similar metabolic background of the dementia. Many findings in the oxidative metabolism of DS suggest increased oxidative damage with an elevation of the turnover of superoxides to peroxides within cells and with a secondary biochemical modification such as increase in tissual GSH-Px activity. A similar mechanism with elevated peroxidation within cells might be responsible for the present finding of increased GSH-Px activity in erythrocytes and for the development of dementia in AD/...Continue Reading

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Citations

Jan 1, 1995·Life Sciences·A C Bowling, M F Beal
Jan 1, 1988·Free Radical Biology & Medicine·J Kedziora, G Bartosz
Mar 1, 1996·Schizophrenia Research·S MukerjeeH Kelkar
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Oct 7, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jenny ApeltReinhard Schliebs
Mar 16, 2007·Phytotherapy Research : PTR·Yashodharan KumarasamySatyajit D Sarker
Mar 15, 2006·International Journal of Geriatric Psychiatry·Tae-Suk KimChang-Uk Lee
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Aug 28, 2007·Neurochemical Research·Angela CasadoRosario de La Torre
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Apr 21, 2006·Neurobiology of Aging·Marianna ZanaJános Kálmán

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