PMID: 7524265Aug 1, 1994Paper

Increased granulocyte-colony stimulating factor (G-CSF) levels in neonates with perinatal complications

Acta Paediatrica Japonica; Overseas Edition
K Ikeno

Abstract

We have investigated cord blood granulocyte-colony stimulating factor (G-CSF) levels in neonates with or without neonatal complications to examine some changes in the G-CSF levels in the neonatal period. The G-CSF levels were measured in 613 neonates by enzyme immunoassay. The results showed that G-CSF levels were distributed in a broad range from the level under the cutting point (31 pg/mL) to over the measurable range (2000 pg/mL). Normal neonates without perinatal complications were 322. In normal neonates, the G-CSF level correlated with the gestational age (r = 0.255, P < 0.01) and cord blood leukocyte count (r = 0.210, P < 0.01). The G-CSF values were under 100 pg/mL in 95% of normal neonates with a median of 35.0 pg/mL. We divided the neonates into two groups: a lower (< 100 pg/mL) and a higher (> or = 100 pg/mL), based on the G-CSF level. The percentage of neonates with higher G-CSF levels (> or = 100 pg/mL) was greater in neonates with perinatal complications than in normal neonates (< 100 pg/mL; P < 0.01). Compared with normal neonates, the percentages of the higher group were greater in neonates with infections (P < 0.01), fetal distress (P < 0.01), premature rupture of membranes (P < 0.05), neonatal asphyxia (P < 0....Continue Reading

References

Jul 1, 1991·American Journal of Diseases of Children·R L RobertsJ A Glaspy
May 1, 1991·The Australian & New Zealand Journal of Obstetrics & Gynaecology·H CoughtreyV Poulos
Mar 31, 1989·Journal of Immunological Methods·H MotojimaM Fukushima
Jan 1, 1989·American Journal of Diseases of Children·M S Cairo
Feb 1, 1987·American Journal of Obstetrics and Gynecology·A Ohlsson, M Vearncombe
Feb 1, 1981·British Journal of Obstetrics and Gynaecology·S W D'SouzaB Richards

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