Increased Gs Signaling in Osteoblasts Reduces Bone Marrow and Whole-Body Adiposity in Male Mice

Endocrinology
Corey J CainEdward C Hsiao

Abstract

Bone is increasingly recognized as an endocrine organ that can regulate systemic hormones and metabolism through secreted factors. Although bone loss and increased adiposity appear to be linked clinically, whether conditions of increased bone formation can also change systemic metabolism remains unclear. In this study, we examined how increased osteogenesis affects metabolism by using an engineered G protein-coupled receptor, Rs1, to activate Gs signaling in osteoblastic cells in ColI(2.3)(+)/Rs1(+) transgenic mice. We previously showed that these mice have dramatically increased bone formation resembling fibrous dysplasia of the bone. We found that total body fat was significantly reduced starting at 3 weeks of age. Furthermore, ColI(2.3)(+)/Rs1(+) mice showed reduced O2 consumption and respiratory quotient measures without effects on food intake and energy expenditure. The mice had significantly decreased serum triacylglycerides, leptin, and adiponectin. Resting glucose and insulin levels were unchanged; however, glucose and insulin tolerance tests revealed increased sensitivity to insulin. The mice showed resistance to fat accumulation from a high-fat diet. Furthermore, ColI(2.3)(+)/Rs1(+) mouse bones had dramatically reduce...Continue Reading

References

Jun 11, 2004·The Journal of Biological Chemistry·Kenneth A LongoOrmond A MacDougald
Jan 30, 2007·Diabetes·Wendy S WrightOrmond A MacDougald
Aug 22, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Christina N BennettOrmond A MacDougald
Jan 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Edward C HsiaoRobert A Nissenson
Mar 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Mathieu FerronPatricia Ducy
Aug 1, 2008·Nature Methods·Bruce R ConklinBryan L Roth
Mar 3, 2009·Cellular Signalling·Nabanita S Datta, Abdul B Abou-Samra
Apr 2, 2009·American Journal of Physiology. Endocrinology and Metabolism·Kazuharu Takeuchi, Karen Reue
Apr 28, 2009·Critical Reviews in Eukaryotic Gene Expression·Clifford J RosenAna Maria Pino
May 27, 2009·Nature Reviews. Rheumatology·Masanobu KawaiClifford J Rosen
Sep 19, 2009·PLoS Computational Biology·Juen Guo, Kevin D Hall
Dec 23, 2009·The International Journal of Biochemistry & Cell Biology·Maryam AhmadianHei Sook Sul
Feb 19, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·I KanazawaT Sugimoto
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Edward C HsiaoBruce R Conklin
Jun 3, 2010·Frontiers in Bioscience (Landmark Edition)·Mengrui WuYi-Ping Li
Aug 18, 2010·Disease Models & Mechanisms·Julio E AyalaUNKNOWN NIH Mouse Metabolic Phenotyping Center Consortium
Apr 29, 2011·Calcified Tissue International·G J KazakiaE C Hsiao
Jun 17, 2011·Journal of Orthopaedic Surgery and Research·Jay J Cao
Aug 4, 2011·American Journal of Physiology. Endocrinology and Metabolism·Wentong PanNicola Abate
Apr 3, 2012·Annual Review of Biochemistry·Qi Qun Tang, M Daniel Lane
Jun 19, 2012·Journal of Internal Medicine·M KawaiC J Rosen
Jun 26, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lige SongJun Guo
Jul 4, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Y RavussinR L Leibel
Jul 14, 2012·Nature Reviews. Drug Discovery·Clara C BladStefan Offermanns
Jul 21, 2012·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yanjun ZhangJulia Wanjiru Kimondo
Nov 14, 2012·Nature Reviews. Endocrinology·Sarah L BoothCaren Gundberg
Feb 5, 2013·Frontiers of Medicine·Wenbo Yan, Xin Li
Feb 9, 2013·The Journal of Clinical Endocrinology and Metabolism·Pouneh K FazeliAnne Klibanski
Apr 26, 2013·The Journal of Clinical Endocrinology and Metabolism·Barbara A GowerWesley M Granger
Oct 12, 2013·Journal of Cellular Physiology·Anna Eisenstein, Katya Ravid
Feb 1, 2014·Methods in Enzymology·Sebastian D ParleeOrmond A MacDougald
May 9, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Partha SinhaJoy Y Wu
Jun 24, 2014·Archives of Biochemistry and Biophysics·Beata Lecka-Czernik, Lance A Stechschulte
Jan 13, 2015·Reviews in Endocrine & Metabolic Disorders·Jianwen Wei, Gerard Karsenty

❮ Previous
Next ❯

Citations

Nov 9, 2019·Annual Review of Physiology·Francisco J A de Paula, Clifford J Rosen
Feb 11, 2020·Frontiers in Endocrinology·Hsuan LungKelly L Wentworth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.