Increased HDL Size and Enhanced Apo A-I Catabolic Rates Are Associated With Doxorubicin-Induced Proteinuria in New Zealand White Rabbits

Lipids
Victoria López-OlmosOscar Pérez-Méndez

Abstract

The catabolism and structure of high-density lipoproteins (HDL) may be the determining factor of their atheroprotective properties. To better understand the role of the kidney in HDL catabolism, here we characterized HDL subclasses and the catabolic rates of apo A-I in a rabbit model of proteinuria. Proteinuria was induced by intravenous administration of doxorubicin in New Zealand white rabbits (n = 10). HDL size and HDL subclass lipids were assessed by electrophoresis of the isolated lipoproteins. The catabolic rate of HDL-apo A-I was evaluated by exogenous radiolabelling with iodine-131. Doxorubicin induced significant proteinuria after 4 weeks (4.47 ± 0.55 vs. 0.30 ± 0.02 g/L of protein in urine, P < 0.001) associated with increased uremia, creatininemia, and cardiotoxicity. Large HDL2b augmented significantly during proteinuria, whereas small HDL3b and HDL3c decreased compared to basal conditions. HDL2b, HDL2a, and HDL3a subclasses were enriched with triacylglycerols in proteinuric animals as determined by the triacylglycerol-to-phospholipid ratio; the cholesterol content in HDL subclasses remained unchanged. The fractional catabolic rate (FCR) of [(131)I]-apo A-I in the proteinuric rabbits was faster (FCR = 0.036 h(-1)) c...Continue Reading

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Citations

Jun 5, 2016·Progress in Biophysics and Molecular Biology·Christine BaumgartnerMartin Ungerer
May 7, 2019·Journal of Cardiovascular Pharmacology and Therapeutics·Andrea Mondragón-GarcíaÓscar Pérez-Méndez
Apr 26, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yohei TsuchidaValentina Kon
Apr 20, 2021·The Veterinary Record·Miguel Gallego Agúndez, Naima Cassez Porquet

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