Increased hepcidin expression in non-small cell lung cancer tissue and serum is associated with clinical stage

Thoracic Cancer
Qian ChenFenglei Yu

Abstract

Hepcidin is a small secreted peptide that plays a key role in iron metabolism. A high level of hepcidin expression may be implicated in colorectal cancer; however, the relationship between hepcidin and lung cancer has not yet been studied. Serum hepcidin-25, bone morphogenetic protein (BMP)-2, and interleukin (IL)-6 concentration in 53 patients and 16 non-cancerous individuals was measured by enzyme-linked immune sorbent assay. Reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) was utilized to study the expression of hepcidin mRNA in paired tumor and non-tumor lung tissues in surgical specimens from 65 patients with non small cell lung cancer (NSCLC), as well as in six types of lung cancer cell lines and human bronchial epithelial (HBE) cells. Hepcidin protein expression and cellular localization in NSCLC was determined by immunohistochemistry. The serum hepcidin-25 concentration was higher in patients with NSCLC than in non-cancerous individuals, and was positively correlated with serum BMP2 concentration, but negatively with serum IL-6 levels. Serum hepcidin was also correlated with lymph node metastasis and clinical stage. Hepcidin mRNA expression was higher in cancerous tissues of NSCLC than in normal pu...Continue Reading

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Citations

Oct 27, 2018·Journal of Cellular Physiology·Dandan DongPeng Shang
Feb 3, 2018·Experimental & Molecular Medicine·Driton Vela, Zana Vela-Gaxha
Feb 20, 2019·Pharmaceuticals·Vida ZhangAirie Kim
Nov 2, 2017·Frontiers in Physiology·Jean-Christophe DescheminSophie Vaulont
May 16, 2019·Scientific Reports·Ahmed MoghiebCharles Ansong
Nov 30, 2019·Pharmaceuticals·Zachary J HawulaGautam Rishi
Dec 9, 2020·Cells·Myriam Y HsuPaolo E Porporato
Feb 26, 2021·Oxidative Medicine and Cellular Longevity·Lesang ShenJian Huang
Apr 28, 2021·Experimental and Molecular Pathology·Sujani M K GamageVinod Gopalan
Dec 7, 2021·Journal of Biomolecular Structure & Dynamics·Wan-Atirah AzeminMohd Shahir Shamsir

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