Increased heterogeneity of airway calibre in adult rats after hypoxia-induced intrauterine growth restriction

Respirology : Official Journal of the Asian Pacific Society of Respirology
Kimberley C W WangPeter B Noble

Abstract

Intrauterine growth restriction (IUGR) is associated with asthma development. We hypothesized that IUGR disrupts airway development leading to postnatal structural abnormalities of the airway that predispose to disease. This study therefore examined structural changes to the airway and lung in a rat model of maternal hypoxia-induced IUGR. Pregnant rats were housed under hypoxic conditions (11.5% O2 ) from gestational days (GDs) 13 to 20 (pseudoglandular-canalicular stages, i.e. period of airway development) and then returned to normoxic conditions (21% O2 ). A control group of pregnant rats was housed under normoxic conditions throughout pregnancy. Weights of male offspring were recorded at birth and 7 weeks of age (adulthood), at which point lungs were fixed for morphometry and stereology (n = 6/group), or bronchoalveolar lavage fluid (BALF) was collected for cell counts (n = 6/group). IUGR offspring were lighter at birth compared with control, but not at 7 weeks. While there was no difference in mean airway dimensions or lung volume, there was greater anatomical variation in airway lumen area in the IUGR group. A mathematical model of the human lung was used to show that greater heterogeneity in lumen area in IUGR-affected in...Continue Reading

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Citations

Jun 8, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Christopher D Pascoe
Mar 5, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Melissa J BentonJudith C W Mak
Dec 23, 2017·Clinical Science·Kimberley C W WangPeter B Noble
Aug 18, 2020·Journal of Developmental Origins of Health and Disease·Kevin LooiKimberley C W Wang
Sep 20, 2019·Pediatric Pulmonology·Maddison R FrancisKimberley C W Wang
Sep 12, 2019·Frontiers in Physiology·Peter B NobleKimberley C W Wang
Oct 14, 2020·Reproductive Toxicology·J B ArmengaudU Simeoni
Mar 4, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Xian Wen SunQing Yun Li
Jun 24, 2021·Physiology·Kimberley C W WangPeter B Noble

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