Increased Hip Intracapsular Pressure Decreases Perfusion of the Capital Femoral Epiphysis in a Skeletally Immature Porcine Model

Journal of Pediatric Orthopedics
Vidyadhar V UpasaniTim Schrader

Abstract

Increased intracapsular hip pressure is thought to be one of the possible etiologies of femoral head avascular necrosis after intra-articular proximal femoral fractures or acute slipped capital femoral epiphysis. The purpose of this study was to evaluate the relationship between intra-articular hip pressure (IAP) and epiphyseal perfusion pressure (EPP), and its dependency on skeletal maturity using a porcine model. Seven female Yorkshire-hybrid pigs were used to study the direct relationship between IAP and EPP. A needle inserted into the capsule provided both IAP monitoring and saline infiltration until IAP was above mean arterial pressure (MAP). Video simultaneously documented IAP, EPP, MAP. Parameters for all trials in each hip were averaged and compared between the 2 age groups. Significance was P<0.05. Four young hips (in pigs 10.3±1.0 wk, 27.4±2.0 kg) and 5 older hips (21.1±0.1 wk, 89.4±7.1 kg) were studied. There was no significant difference in the MAP (50.0±11.8 and 55.5±7.0 mm Hg respectively, P=0.411) between the 2 age groups. In the older hips, biphasic EPP persisted despite increasing IAP to an average of 177 mm Hg over MAP. In the young pigs, the biphasic EPP waveform ceased with increased IAP to an average of 28 ...Continue Reading

References

Mar 1, 1988·The Journal of Bone and Joint Surgery. British Volume·E J CrawfurdB G Andrews
Aug 1, 1993·The Journal of Bone and Joint Surgery. American Volume·R T LoderD D Aronson
Apr 15, 1999·Journal of Medical Engineering & Technology·M H MorgallaT Katzenberger
Nov 24, 1999·Journal of Medical Engineering & Technology·M H MorgallaE H Grote
May 3, 2003·The Journal of Bone and Joint Surgery. American Volume·Keti P TokmakovaDan E Mason
Jul 9, 2004·Clinical Orthopaedics and Related Research·Martin BeckReinhold Ganz
Dec 24, 2005·Acta neurochirurgica·M Gelabert-GonzálezR M Rumbo
Sep 25, 2008·Journal of Pediatric Orthopedics·Jose A Herrera-SotoKelly L Vander Have
Dec 23, 2008·Journal of Pediatric Orthopedics·Klaus ParschDominik Parsch
May 5, 2009·The Journal of Bone and Joint Surgery. American Volume·Harry K W KimHaikuo Bian
Jan 28, 2010·Journal of Pediatric Orthopedics·Ryan C ChenJ Eric Gordon
Mar 9, 2010·Journal of Orthopaedic Surgery and Research·Ping ZhangHiroki Yokota
Jul 12, 2011·The Orthopedic Clinics of North America·Harry K W Kim, John A Herring
Jan 5, 2013·Clinical Orthopaedics and Related Research·Ira ZaltzJohn C Clohisy
Feb 12, 2013·Clinical Orthopaedics and Related Research·Kai ZiebarthReinhold Ganz
Mar 18, 2015·Journal of Children's Orthopaedics·Talal IbrahimDavid G Little
Jun 17, 2016·The Journal of Bone and Joint Surgery. American Volume·Tim SchraderMackenzie M Herzog

❮ Previous
Next ❯

Citations

Dec 29, 2020·The Journal of Bone and Joint Surgery. American Volume·Lindsay M Andras, Oussama Abousamra

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Critical Care
Isabel M Murcia-SáezAntonio S Salinas-Sánchez
Trends in Genetics : TIG
Martin Holcik
Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Raul Urrutia
© 2021 Meta ULC. All rights reserved