PMID: 15385729Sep 24, 2004Paper

Increased HIV-1 mucosal replication is associated with generalized mucosal cytokine activation

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Ian McGowanPeter Anton

Abstract

The purpose of this study was to characterize intestinal mucosal cytokine profiles in subjects with HIV-1 infection and their relation to mucosal viral load (MVL). Intestinal mucosal cytokine mRNA (interleukin [IL]-2, interferon [IFN]-gamma, IL-12, IL-10, IL-1beta, tumor necrosis factor [TNF]-alpha, IL-6, and regulated upon activation, normal T-cell expressed and secreted [RANTES]) and HIV-1 RNA were quantified using real-time polymerase chain reaction (PCR). On the basis of MVL quantification, the HIV-1-infected subjects were divided into 3 groups: undetectable MVL (<50 copies/microg of tissue total RNA), low MVL (>50 but <5000 copies/microg of tissue total RNA), and high MVL (>5000 copies/microg of tissue total RNA). Compared with the control group, significant reductions in RANTES, IL-2, and IFNgamma expression were seen in the undetectable MVL group (P < 0.005). IL-6 was significantly increased in all the HIV groups (P < 0.005), and RANTES, IL-10, and IFNgamma were increased in the high MVL group (P < 0.005). Subjects with high MVL have generalized immune activation with increases in T helper (Th)1, Th2, and proinflammatory cytokines, whereas subjects with undetectable MVL have reduced expression of multiple cytokines. The ...Continue Reading

References

Mar 1, 1993·Immunology Today·M Clerici, G M Shearer
Jun 1, 1993·Digestive Diseases and Sciences·D P KotlerF Clayton
Dec 1, 1999·Inflammatory Bowel Diseases·S Romagnani
Feb 24, 2000·The American Journal of Gastroenterology·K E MönkemüllerC M Wilcox
Jul 24, 2003·Nature Reviews. Immunology·Gerd Bouma, Warren Strober
Apr 7, 2004·The Journal of Clinical Investigation·Steven G Deeks, Bruce D Walker

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Citations

Aug 11, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Patricia E MolinaCurtis Vande Stouwe
Mar 7, 2007·Current HIV/AIDS Reports·Satya Dandekar
Feb 23, 2010·Current Infectious Disease Reports·Barbara L Shacklett, Peter A Anton
Dec 17, 2008·Mucosal Immunology·J M Brenchley, D C Douek
Aug 27, 2009·Nature Reviews. Gastroenterology & Hepatology·Siew C Ng, Brian Gazzard
Apr 18, 2009·Current Opinion in HIV and AIDS·Jason M Brenchley, Daniel C Douek
Jun 25, 2008·Antimicrobial Agents and Chemotherapy·Hubert SchulbinUNKNOWN Kompetenznetz HIV/AIDS Germany
Jul 10, 2010·PLoS Pathogens·Timothy M HanleyGregory A Viglianti
Jun 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sumathi SankaranSatya Dandekar
Dec 8, 2010·Journal of Clinical Immunology·Joana HyginoCleonice Alves de Melo Bento
Oct 31, 2013·Expert Review of Clinical Immunology·Marta MassanellaJulià Blanco
Nov 26, 2013·Expert Opinion on Drug Delivery·Ian McGowan
Oct 30, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Joana HyginoCleonice A M Bento
Jun 30, 2012·Cytokine & Growth Factor Reviews·Claire VandergeetenNicolas Chomont
Mar 22, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Joana HyginoCleonice A M Bento
Aug 8, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L ChangE A Mayer
Jun 27, 2012·Annals of the New York Academy of Sciences·Hans-Jörg Epple, Martin Zeitz
Jan 8, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sonia Gauthier, Michel J Tremblay
Feb 9, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jennifer A FulcherPamina M Gorbach
Sep 9, 2017·AIDS Research and Human Retroviruses·Shahzada KhanShomyseh Sanjabi
Jun 26, 2018·AIDS Research and Human Retroviruses·Rhonda M BrandIan McGowan

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