Increased HLA-DR expression on tissue eosinophils in eosinophilic esophagitis

Journal of Pediatric Gastroenterology and Nutrition
Anup PatelKari Nadeau

Abstract

The aim of the study was to investigate whether eosinophils have increased human leukocyte antigen (HLA)-DR expression in subjects with eosinophilic esophagitis (EoE) compared with controls. Patients who were undergoing an upper endoscopy with biopsies for suspected gastroesophageal reflux disease (GERD) or EoE at Lucile Packard Children's Hospital were enrolled. In total, the blood and tissue samples of 10 healthy controls (HC), 11 subjects with GERD, and 10 with EoE were studied. Multiple tissue staining to identify eosinophils (via eosinophil cationic protein-clone EG2) and major histocompatibility complex class II cell surface receptors (via HLA-DR) was performed via immunohistochemistry. The peripheral blood was analyzed using flow cytometry to detect eosinophil HLA-DR expression among these subjects. In the tissue, a greater proportion of eosinophils expressed HLA-DR among the subjects with EoE (mean 0.83 +/- 0.14, n = 9) relative to those with GERD (mean 0.18 +/- 0.19, n = 8, P < 0.01) and HC (mean 0.18 +/- 0.13, n = 6, P < 0.01). In total, 6 participants (4 HC subjects and 2 subjects with GERD) did not have any eosinophils identified on tissue staining and were unable to be included in the present statistical analysis. ...Continue Reading

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Citations

Jan 7, 2014·International Journal of Biological Sciences·Qing-Song ZhaoZhi-Feng Cheng
May 13, 2014·Gastroenterology Clinics of North America·Joshua B Wechsler, Paul J Bryce
Apr 12, 2011·The Journal of Allergy and Clinical Immunology·Chris A LiacourasSeema S Aceves
Nov 5, 2016·Immunology·Ruhaifah K FarhanGarry M Walsh
Feb 6, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Hamish PhilpottEvan S Dellon
Dec 19, 2020·Frontiers in Immunology·Alfred D DoyleBenjamin L Wright
Nov 8, 2012·Journal of Pediatric Gastroenterology and Nutrition·Benjamin P Davis, Marc E Rothenberg
Oct 13, 2012·Journal of Pediatric Gastroenterology and Nutrition·Minou Le-CarlsonKari C Nadeau
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May 18, 2011·Current Opinion in Gastroenterology·Glenn T Furuta

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