Increased HOX C13 expression in metastatic melanoma progression.

Journal of Translational Medicine
M CantileGerardo Botti

Abstract

The process of malignant transformation, progression and metastasis of melanoma is not completely understood. Recently, the microarray technology has been used to survey transcriptional differences that might provide insight into the metastatic process, but the validation of changing gene expression during metastatic transition period is poorly investigated. A large body of literature has been produced on the role of the HOX genes network in tumour evolution, suggesting the involvement of HOX genes in several types of human cancers. Deregulated paralogous group 13 HOX genes expression has been detected in melanoma, cervical cancer and odonthogenic tumors. Among these, Hox C13 is also involved in the expression control of the human keratin genes hHa5 and hHa2, and recently it was identified as a member of human DNA replication complexes. In this study, to investigate HOX C13 expression in melanoma progression, we have compared its expression pattern between naevi, primary melanoma and metastasis. In addition HOXC13 profile pattern of expression has been evaluated in melanoma cell lines. Our results show the strong and progressive HOX C13 overexpression in metastatic melanoma tissues and cytological samples compared to nevi and p...Continue Reading

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Citations

Nov 6, 2013·International Journal of Molecular Sciences·Monica CantileGerardo Botti
Jul 6, 2014·Virchows Archiv : an International Journal of Pathology·Gerardo BottiMonica Cantile
Jul 6, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Seema BhatlekarBruce M Boman
Jun 25, 2014·Proceedings of the National Academy of Sciences of the United States of America·Cailin CollinsJay L Hess
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May 27, 2016·International Journal of Cancer. Journal International Du Cancer·Zoe KellyAgnieszka Michael
Jan 10, 2017·Journal of Cellular Physiology·Monica CantileGerardo Botti
Aug 23, 2018·Journal of Cellular Physiology·Gerardo BottiMonica Cantile
Dec 15, 2016·Oncotarget·Justin KomisarofHartmut Land
Jul 1, 2016·Oncotarget·Kristina von HeykingGuenther Hs Richter
May 30, 2019·Cancers·Gerardo BottiMonica Cantile
Dec 14, 2018·Journal of Translational Medicine·Fabiana TatangeloGerardo Botti
May 18, 2019·Carcinogenesis·Vincent T JanmaatMaikel P Peppelenbosch
Oct 8, 2021·Cell Biology and Toxicology·U Sangeetha ShenoyRaghu Radhakrishnan

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Methods Mentioned

BETA
PCR
Assay
biopsy
antisense oligonucleotide

Software Mentioned

Statistical Package for Social Science

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