Increased human menopausal gonadotropin dose during the early follicular phase: effect on follicular recruitment and treatment outcome

Journal of in Vitro Fertilization and Embryo Transfer : IVF
J BlanksteinM M Quigley

Abstract

To investigate whether the provision of increased gonadotropins would enhance follicular recruitment and selection, women not responding (N = 18) to our standard clomiphene citrate (CC)-human menopausal gonadotropin (hMG) regimen were treated with increased hMG (treatment cycle II). Estradiol levels were higher in treatment cycle II and these differences were significant on days 8 and 9 (P less than or equal to 0.05 and P less than or equal to 0.03, respectively). On day 9, better follicular development was seen in cycle II (P less than or equal to 0.05). While none of the patients responded in cycle I, 10 of 18 responded in cycle II. Of the 10 responders, 2 conceived following in vitro fertilization and embryo placement. Increasing the dose of hMG improved the development of a cohort of follicles so that aspiration and possible pregnancy were achieved in women who were previously unresponsive to therapy.

References

Mar 1, 1985·Journal of in Vitro Fertilization and Embryo Transfer : IVF·A M DlugiF Naftolin
Jun 1, 1985·Journal of in Vitro Fertilization and Embryo Transfer : IVF·S C NgC Anandakumar
Dec 1, 1985·Fertility and Sterility·M M QuigleyS I Richards
Mar 1, 1983·Fertility and Sterility·F GeisthövelM Breckwoldt
Jan 1, 1981·Endocrine Reviews·G S diZerega, G D Hodgen

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Citations

Apr 1, 1995·Journal of Assisted Reproduction and Genetics·M H van Hooff

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