Increased hypolipidemic benefits of cis-9, trans-11 conjugated linoleic acid in combination with trans-11 vaccenic acid in a rodent model of the metabolic syndrome, the JCR:LA-cp rat.

Nutrition & Metabolism
Maria M Jacome-SosaSpencer D Proctor

Abstract

Conjugated linoleic acid (cis-9, trans-11 CLA) and trans-11 vaccenic acid (VA) are found naturally in ruminant-derived foods. CLA has been shown to have numerous potential health related effects and has been extensively investigated. More recently, we have shown that VA has lipid-lowering properties associated with reduced hepatic lipidogenesis and chylomicron secretion in the JCR:LA-cp rat. The aim of this study was to evaluate potential additional hypolipidemic effects of purified forms of CLA and VA in an animal model of the metabolic syndrome (the JCR:LA-cp rat). Twenty four obese JCR:LA-cp rats were randomized and assigned to one of three nutritionally adequate iso-caloric diets containing 1% w/w cholesterol and 15% w/w fat for 16 wk: 1) control diet (CD), 2) 1.0% w/w cis-9, trans-11 CLA (CLA), 3) 1.0% w/w VA and 1% w/w cis-9, trans-11 CLA (VA+CLA). Lean rats were fed the CD to represent normolipidemic conditions. Fasting plasma triglyceride (TG), total cholesterol and LDL-cholesterol concentrations were reduced in obese rats fed either the CLA diet or the VA+CLA diet as compared to the obese control group (p < 0.05, p < 0.001; p < 0.001, p < 0.01; p < 0.01, p < 0.001, respectively). The VA+CLA diet reduced plasma TG and L...Continue Reading

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Citations

Jun 19, 2013·Critical Reviews in Food Science and Nutrition·L TriguerosE Sendra
Apr 30, 2014·The Journal of Nutritional Biochemistry·M Miriam Jacome-SosaSpencer D Proctor
Dec 1, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rabban MangatSpencer D Proctor
Mar 25, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·X SunG W Krissansen
Sep 13, 2019·Journal of Agricultural and Food Chemistry·Tatiane Lima AmorimPilar Gómez-Cortés
Sep 25, 2021·Scientific Reports·Larissa de Brito MedeirosRita de Cassia Ramos do Egypto Queiroga

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