Increased IgG1, IFN-gamma, TNF-alpha and IL-6 responses to Mycobacterium tuberculosis antigens in patients with tuberculosis are lower after chemotherapy

International Immunology
Ana Márcia M MattosHenrique C Teixeira

Abstract

Detection of specific antibodies may represent an additional tool in diagnosis of tuberculosis (TB). Herein, levels of serum IgG antibodies against early secreted antigenic target (ESAT-6), culture filtrate antigen-10 (CFP-10) and 16 kDa Mycobacterium tuberculosis antigens were measured in 33 active pulmonary TB patients (0M-TB), in 47 patients after 1-3 months of treatment (3M-TB) and in 22 patients who had completed 6 months of chemotherapy (6M-TB). The control group consisted of 38 BCG-vaccinated healthy controls (HC). In addition, IFN-gamma, tumor necrosis factor (TNF)-alpha, IL-6, IL-2, IL-4 and IL-10 production in PBMC cultures from 20 patients were measured following stimulation with the M. tuberculosis-specific fusion protein ESAT-6/CFP-10. Elevated levels of IgG against ESAT-6, CFP-10 and 16 kDa antigens were detected in 0M-TB and 3M-TB patients in comparison to the HC and 6M-TB groups. Receiver operating characteristic analysis indicated sensitivity of 85, 94 and 61% and specificity of 89, 87 and 89% for serum IgG against ESAT-6, CFP-10 and 16 kDa, respectively. A predominant IgG1 response to ESAT-6 and CFP-10 was observed in 0M-TB patients, together with ESAT-6/CFP-10-specific IFN-gamma, TNF-alpha and IL-6 that were ...Continue Reading

References

Nov 1, 1991·Trends in Biotechnology·M W Fanger, P M Guyre
Jan 11, 1990·Annual Review of Immunology·F D FinkelmanW E Paul
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·I H ChiangP C Yang
Jul 23, 1998·Infection and Immunity·K LyashchenkoM L Gennaro
Mar 7, 2000·Clinical and Diagnostic Laboratory Immunology·L A van PinxterenP Andersen
Jul 3, 2002·Clinical and Diagnostic Laboratory Immunology·Rodrigo Ribeiro-RodriguesChristina S Hirsch
Dec 14, 2002·Immunity·Bernd ElserMin Li-Weber
Aug 25, 2004·Trends in Immunology·Graham A W RookGeok Teng Seah
Sep 24, 2005·Infection and Immunity·S de VallièreD F Hoft
Feb 10, 2006·Clinical and Vaccine Immunology : CVI·Abebech DemissieUNKNOWN VACSEL Study Group
May 17, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D GolettiE Girardi
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mischo KursarStefan H E Kaufmann
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takayuki ImanishiTakashi Saito
Jul 20, 2007·Scandinavian Journal of Immunology·F AbebeG Bjune
Aug 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Soren T HoffKarin Weldingh
Aug 9, 2007·Future Microbiology·Karen R SteingartMadhukar Pai
Oct 2, 2007·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Henrique Couto TeixeiraMartin Emilio Munk
Apr 11, 2008·Clinical and Vaccine Immunology : CVI·Kelly Aparecida KanunfreAntonio Walter Ferreira
Feb 7, 2009·Clinical and Experimental Immunology·J F Djoba SiawayaG Walzl
Mar 24, 2009·Annual Review of Immunology·Andrea M Cooper
Jul 17, 2009·Clinical and Experimental Immunology·F Abebe, G Bjune
Dec 23, 2009·Memórias do Instituto Oswaldo Cruz·Caroline de Souza AlmeidaHenrique Couto Teixeira

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Citations

Nov 2, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Q TanH Wang
Jun 19, 2014·BMC Infectious Diseases·Xiaoyan FengHeqiu Zhang
Oct 20, 2014·Cell Biochemistry and Biophysics·Hanwen ChenHongjiang Sun
Jan 24, 2014·SpringerPlus·Prati Pal Singh, Amit Goyal
Jan 22, 2011·Clinical & Developmental Immunology·Gilson C MacedoSergio C Oliveira
Nov 10, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Serene H JohnArchana S Gandhe
Mar 24, 2015·Tuberculosis·Vanessa CliffordNigel Curtis
Feb 23, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·X H GuoN Zhao
Dec 19, 2017·Frontiers in Cellular and Infection Microbiology·Jia-Ni XiaoYing Wang
Apr 9, 2011·Nature Reviews. Immunology·Gerhard WalzlAlimuddin Zumla
Jun 8, 2012·Scandinavian Journal of Immunology·K I MasoodZ Hasan
Apr 11, 2014·Journal of Internal Medicine·A ZumlaM Maeurer
Oct 21, 2016·Expert Review of Anti-infective Therapy·Jan-Willem C AlffenaarDick Van Soolingen
May 15, 2018·The Journal of International Medical Research·Xuejiao LuoHaiyan Cui
Sep 6, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y JiJ-Y Chen
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Aida SivroKogieleum Naidoo
Jul 9, 2021·Frontiers in Cellular and Infection Microbiology·Diego L CostaAlan Sher

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