Increased IL-10-producing regulatory T cells are characteristic of severe cases of COVID-19

Clinical & Translational Immunology
Julika NeumannS. Humblet-Baron

Abstract

The pandemic spread of the coronavirus SARS-CoV-2 is due, in part, to the immunological properties of the host-virus interaction. The clinical presentation varies from individual to individual, with asymptomatic carriers, mild-to-moderate-presenting patients and severely affected patients. Variation in immune response to SARS-CoV-2 may underlie this clinical variation. Using a high-dimensional systems immunology platform, we have analysed the peripheral blood compartment of 6 healthy individuals, 23 mild-to-moderate and 20 severe COVID-19 patients. We identify distinct immunological signatures in the peripheral blood of the mild-to-moderate and severe COVID-19 patients, including T-cell lymphopenia, more consistent with peripheral hypo- than hyper-immune activation. Unique to the severe COVID-19 cases was a large increase in the proportion of IL-10-secreting regulatory T cells, a lineage known to possess anti-inflammatory properties in the lung. As IL-10-secreting regulatory T cells are known to possess anti-inflammatory properties in the lung, their proportional increase could contribute to a more severe COVID-19 phenotype. We openly provide annotated data (https://flowrepository.org/experiments/2713) with clinical correlates ...Continue Reading

References

Feb 13, 2001·Immunity·Sean DiehlM Rincón
Jun 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Koenraad F van der SluijsTom van der Poll
Mar 30, 2007·The American Journal of Pathology·Jiang Gu, Christine Korteweg
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·K Kai McKinstrySusan L Swain
Oct 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jihoon ChangCheong-Hee Chang
Feb 26, 2011·Immunological Reviews·Christina E ZielinskiFederica Sallusto
Mar 23, 2013·Annual Review of Immunology·Kong Chen, Jay K Kolls
May 15, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Felipe BedoyaAndrew J Caton
Mar 18, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Muriel HannonFrédéric Baron
Mar 21, 2015·The European Respiratory Journal·Susanne HeroldG R Scott Budinger
Nov 5, 2016·The Journal of Experimental Medicine·Rui YangMercedes Rincon
Nov 8, 2017·The Journal of Infectious Diseases·Sook-San WongUNKNOWN SHIVERS Investigation Team
Mar 13, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chuan QinDai-Shi Tian
Mar 24, 2020·Cellular & Molecular Immunology·Meijuan ZhengZhigang Tian
Mar 29, 2020·The Journal of Clinical Investigation·Guang ChenQin Ning
Apr 19, 2020·The Lancet. HIV·Jose L BlancoUNKNOWN COVID-19 in HIV Investigators
Apr 26, 2020·The Journal of Allergy and Clinical Immunology·Isabella QuintiAlessandro Plebani
May 1, 2020·Proceedings of the National Academy of Sciences of the United States of America·Xiaoling XuHaiming Wei
May 4, 2020·The Journal of Allergy and Clinical Immunology·Yang YangYingxia Liu
May 8, 2020·Nature Reviews. Immunology·Miriam Merad, Jerome C Martin
May 14, 2020·Nature Medicine·Mingfeng LiaoZheng Zhang
May 15, 2020·The Journal of Allergy and Clinical Immunology·Ruchong ChenUNKNOWN Medical Treatment Expert Group for COVID-19
May 18, 2020·Cell·Daniel Blanco-MeloBenjamin R tenOever
Jun 10, 2020·Nature Medicine·Aaron J WilkCatherine A Blish
Jun 23, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Savannah Karmen-TuohyJoseph Rahimian
Aug 25, 2020·The Lancet. Microbe·Michael J CoxJustin O'Grady

❮ Previous
Next ❯

Citations

Mar 7, 2021·Cytokine & Growth Factor Reviews·Narayanappa AmrutaGregory Bix
Mar 23, 2021·Frontiers in Immunology·Holger A LindnerThomas Kirschning
Apr 4, 2021·International Journal of Molecular Sciences·Fanny PojeroAnna Aiello
Apr 14, 2021·Thorax·Anno SarisUNKNOWN ArtDECO consortium and the Amsterdam UMC COVID study group
Jun 25, 2021·International Immunopharmacology·Alexander Batista-DuharteRafael Solana
Aug 20, 2021·Frontiers in Immunology·Lauren Van ZeebroeckMarkus Kleinewietfeld
Aug 27, 2021·Proceedings of the National Academy of Sciences of the United States of America·Silvia Galván-PeñaChristophe Benoist

❮ Previous
Next ❯

Methods Mentioned

BETA
bronchoalveolar lavage
flow cytometry
lymphodepletion
FCS

Software Mentioned

CONTAGIOUS
FlowRepository
AutoSpill
MIFlowCyt
tSNE
R
FlowJo
FlowSOM

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.