Increased IL-6 in supernatant of rat mesangial cell cultures treated with erythrogenic toxin type B and its precursor isolated from nephritogenic streptococci

American Journal of Nephrology
Adriana PedreáñezJesus Mosquera

Abstract

Previous reports have shown the presence of streptococcal erythrogenic toxin type B (ETB), IL-8, transforming growth factor-beta (TGF-beta) and glomerular proliferation in renal biopsies from patients with acute poststreptococcal glomerulonephritis (APSGN). In addition, increased levels of plasma IL-6 and tumor necrosis factor-alpha (TNFalpha) and urinary IL-6 have also been reported in this disease. To determine the effect of ETB in mesangial cell cytokine production and proliferation, the concentration of several cytokines (IL-6, IL-1beta, TNFalpha, IL-10, IL-4, RANTES), soluble TNF receptor I (STNFR-I), soluble TNF receptor II (STNFR-II) and proliferation were measured in rat mesangial cells cultures after treatment with ETB or its precursor (ETBP). To analyze the levels of cytokines and production of soluble receptors as well as proliferation, rat mesangial cells were cultured with ETB or ETBP (50 microg/ml). After 24, 48 and 96 h of incubation, culture supernatants were assessed for cytokines and receptors by ELISA and for proliferation by incorporation of radioactive thymidine. A significant increase in IL-6 levels was found in mesangial cell cultures treated with either ETBP or ETB when compared with controls. Streptococ...Continue Reading

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Citations

May 29, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ninoska VieraJesus Mosquera
Feb 3, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ninoska VieraJesus Mosquera
Apr 22, 2015·Autoimmunity Reviews·William John MartinIan P Wicks
Mar 12, 2008·Current Opinion in Pediatrics·Sun-Young Ahn, Elizabeth Ingulli
Aug 1, 2008·Journal of the American Society of Nephrology : JASN·Bernardo Rodriguez-Iturbe, James M Musser
Oct 9, 2020·International Reviews of Immunology·Jesús Mosquera, Adriana Pedreañez

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