Increased immunostaining of collagenase and TIMP in eruptive xanthoma.

The American Journal of the Medical Sciences
J W Childers, G P Stricklin

Abstract

Remodeling of the extracellular matrix is an important function of interstitial collagenase. The activity of this enzyme forms the initial and rate limiting step in collagen degradation; moreover, this enzyme appears representative of a family of connective tissue metalloproteinases. Conversely, a widely distributed glycoprotein, tissue inhibitor of metalloproteinases (TIMP), may be an important regulator of matrix degradation. To study the roles of collagenase and TIMP in pathologically altered dermal connective tissue, immunohistochemistry was used to localize collagenase and TIMP in an eruptive xanthoma, a chronic tuberous xanthoma, and normal skin. Normal skin and the chronic tuberous xanthoma showed mild diffuse staining of both proteins throughout the dermis. In contrast, intense dermal staining of both collagenase and TIMP was present in the eruptive xanthoma. Thus, the marked accumulation of lipid in dermal macrophages was associated with a significant increase in matrix collagenase and TIMP. This increase may reflect direct production of these two proteins by macrophages. Alternatively, it may be due to increased production by fibroblasts stimulated by macrophage-derived cytokines. The balance of degradative and inhibi...Continue Reading

References

Oct 1, 1977·The Journal of Investigative Dermatology·E A BauerA Z Eisen
Nov 1, 1975·Arthritis and Rheumatism·D J McCarty, F Kozin
Jun 1, 1987·Arthritis and Rheumatism·K A HastyA H Kang
Dec 1, 1987·Journal of the American Academy of Dermatology·J W ChildersG P Stricklin
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T W CooperH G Welgus
Jul 1, 1985·The Journal of Clinical Investigation·H G WelgusS L Teitelbaum
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·Z Bar-ShavitH G Welgus
Nov 1, 1986·The Journal of Investigative Dermatology·H G WelgusG P Stricklin
May 1, 1969·The Journal of Investigative Dermatology·A Z Eisen
Apr 1, 1974·The Journal of Investigative Dermatology·M E ReddickA Z Eisen
Dec 1, 1984·Collagen and Related Research·E D HarrisS M Krane
Jul 3, 1980·The New England Journal of Medicine·G WeissmannH M Korchak
Feb 1, 1982·Arthritis and Rheumatism·S AbramsonG Weissmann
Feb 1, 1983·The Journal of Experimental Medicine·A E PostlethwaiteA H Kang
Jun 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·J GROSS, C M LAPIERE

❮ Previous
Next ❯

Citations

Feb 1, 1995·The Journal of Investigative Dermatology·E C BullenE W Howard
Oct 1, 1994·The Journal of Investigative Dermatology·G P Stricklin, L B Nanney

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.