Increased in vitro differentiation of fibrocytes from keloid patients is inhibited by serum amyloid P

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Michelle C NaylorOluyinka O Olutoye

Abstract

Keloid scarring is a form of fibroproliferative dermal wound healing characterized by growth beyond the confines of the original wound. Fibrocytes, derived from peripheral blood mononuclear cells and inhibited by serum amyloid P (SAP), have been linked to other fibroproliferative diseases. We hypothesized that peripheral blood mononuclear cells of keloid formers have a higher propensity to differentiate into fibrocytes and are more resistant to the effects of SAP. To test this hypothesis, plasma was isolated from peripheral blood samples of keloid (n = 10) and age/sex/race-matched control (n = 10) subjects, and SAP levels were measured by enzyme-linked immunosorbent assay. Equal numbers of peripheral blood mononuclear cells were also isolated from these samples and fibrocytes cultured in serum-free media with increasing concentrations of SAP. No difference in plasma SAP levels was found between keloid and control subjects. In the absence of SAP, keloid patients (n = 7) had almost 20 times more fibrocytes than controls (n = 7) in culture (median: 1,087 cells vs. 60 cells; p < 0.01). SAP inhibited the differentiation of keloid fibrocytes in vitro, although a higher concentration of SAP was needed when compared with controls (20 μ...Continue Reading

References

Jul 1, 1992·Journal of Clinical Immunology·R L McCauleyM C Robson
Aug 30, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·S R NelsonM B Pepys
Apr 1, 1989·Molecular and Cellular Biology·M BabuN Oliver
Jan 1, 1989·Medical and Pediatric Oncology·P A SiraganianR W Miller
Dec 11, 1971·The Veterinary Record·M A Gething
Dec 1, 1969·Plastic and Reconstructive Surgery·S M Alhady, K Sivanantharajah
Oct 1, 1994·The Journal of Investigative Dermatology·M HaisaG R Grotendorst
Aug 1, 1993·The Journal of Surgical Research·D W FriedmanS B Deak
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·J ChesneyR Bucala
Aug 24, 1999·Annals of Plastic Surgery·T Y LeeM T Longaker
Jul 25, 2000·The British Journal of Dermatology·D E BoyceK Moore
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R AbeC N Metz
Aug 22, 2001·British Journal of Plastic Surgery·D E BoyceK G Harding
Oct 20, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·I HartlappC N Metz
May 25, 2002·Medical Hypotheses·E P Fong, B H Bay
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Darrell PillingRichard H Gomer
Mar 11, 2004·The International Journal of Biochemistry & Cell Biology·Timothy E QuanRichard Bucala
Apr 17, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Thaís P AmadeuAndréa M A Costa
May 14, 2004·The Journal of Investigative Dermatology·Alexander G MarnerosBjorn R Olsen
Jul 13, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Liju YangEdward E Tredget
Jan 13, 2006·Plastic and Reconstructive Surgery·Ali Al-AttarSteven P Davison
Nov 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Sandra B HaudekMark L Entman
Jan 25, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jian Fei WangEdward E Tredget
Jul 4, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Alberto Bellini, Sabrina Mattoli
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Darrell PillingRichard H Gomer
Mar 6, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Bindi Naik-MathuriaOluyinka O Olutoye
Jun 20, 2008·Journal of Dermatological Science·Wen-Sheng LuXue-Jun Zhang
Oct 24, 2009·The International Journal of Biochemistry & Cell Biology·Ellen C KeeleyRobert M Strieter
Oct 31, 2009·Clinical and Experimental Dermatology·J J BrownA Bayat
Dec 17, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Barbara ShihArdeshir Bayat
Jun 22, 2010·Molecular and Cellular Biochemistry·Abelardo Medina, Aziz Ghahary

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Citations

Aug 21, 2013·Current Allergy and Asthma Reports·Richard H Gomer
Jun 13, 2019·Archives of Dermatological Research·Grace C LimandjajaSusan Gibbs
Nov 22, 2018·Frontiers in Immunology·Darrell Pilling, Richard H Gomer
Jun 13, 2020·Frontiers in Cell and Developmental Biology·Grace C LimandjajaSusan Gibbs

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