Increased incidence of congenital hypothyroidism in France from 1982 to 2012: a nationwide multicenter analysis

Annals of Epidemiology
Yaya BarryMichel Roussey

Abstract

Recent studies have shown an increased incidence of congenital hypothyroidism over the past 2 or 3 decades. The etiology of this change is unknown, but it has been related by several authors to lowering of cutoffs. We sought to determine whether the incidence of congenital hypothyroidism (CH) in France has changed. We analyzed data from the nationwide neonatal screening program for CH during the period 1982-2012. We included all children having thyroid-stimulating hormone values above the threshold and for whom diagnosis of CH confirmed by the pediatrician. We estimated multicentric temporal trends in the annual incidence rates adjusted for screening methods for thyroid dysgenesis and eutopic gland. We found 6622 cases of CH (28.0 per 100,000 newborns); 1895 had a eutopic gland, and 4727 had thyroid dysgenesis. The incidence of eutopic glands showed a significant annual average increase of (5.1%; 95% confidence interval: 4.3-5.9) regardless of the screening method or screening center. This increase was confirmed in severe cases (thyroid-stimulating hormone ≥ 50: 2.1%; 95% confidence interval, 1.4-2.9). The incidence of dysgenesis remained constant. The incidence of eutopic glands increased in France, not only in mild forms but ...Continue Reading

References

Dec 1, 1995·The Journal of Obstetrics and Gynaecology·Y KogaM Kawamura
May 10, 2001·The Journal of Clinical Endocrinology and Metabolism·M CastanetUNKNOWN AFDPHE (Association Française pour le Dépistage et la Prévention des Handicaps de l'Enfant)
May 3, 2005·Journal of Medical Genetics·S M Park, V K K Chatterjee
May 22, 2007·Molecular Genetics and Metabolism·Katharine B Harris, Kenneth A Pass
May 15, 2010·Pediatrics·Vicki HertzbergBradford L Therrell
Jul 2, 2010·The Journal of Clinical Endocrinology and Metabolism·Chryssanthi MengreliCatherine Dacou-Voutetakis
Jun 1, 2011·Clinical Endocrinology·Marvin L MitchellUNKNOWN Massachusetts Pediatric Endocrine Work Group
Jun 3, 2011·The Journal of Clinical Endocrinology and Metabolism·Johnny DeladoëyGuy Van Vliet
May 23, 2012·Journal de gynécologie, obstétrique et biologie de la reproduction·B BlondelUNKNOWN National Coordination Group of the National Perinatal Surveys
Jun 23, 2012·The Journal of Clinical Endocrinology and Metabolism·Benjamin B AlbertPaul L Hofman
Feb 28, 2013·The Journal of Clinical Endocrinology and Metabolism·Antonella OlivieriUNKNOWN Italian Study Group for Congenital Hypothyroidism
Sep 7, 2013·Hormone Research in Pædiatrics·Ana ChiesaLaura Gruñeiro-Papendieck
Jan 23, 2014·The Journal of Clinical Endocrinology and Metabolism·Juliane LégerUNKNOWN Congenital Hypothyroidism Consensus Conference Group
Mar 19, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·George Ford, Stephen H LaFranchi
Mar 26, 2014·Hormone Research in Pædiatrics·Juliane LégerUNKNOWN Congenital Hypothyroidism Consensus Conference Group
Jan 13, 2015·Hormone Research in Pædiatrics·Antonella OlivieriUNKNOWN Italian Study Group for Congenital Hypothyroidism
Jan 31, 2015·Hormone Research in Pædiatrics·Mireille CastanetUNKNOWN Fédération Parisienne pour le Dépistage et la Prévention des Handicaps de l''Enfant (FDPHE)

❮ Previous
Next ❯

Citations

May 2, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Kui DengYanping Wang
May 24, 2018·Thyroid : Official Journal of the American Thyroid Association·Athanasia StoupaAurore Carré
Jul 4, 2018·Thyroid : Official Journal of the American Thyroid Association·Carole SabaJuliane Léger
Jul 12, 2017·European Journal of Endocrinology·Samantha LainGuy Van Vliet
Jul 6, 2019·Biologie aujourd'hui·Juliane Léger
Jul 6, 2019·Biologie aujourd'hui·Jean-Baptiste Fini, Barbara Demeneix
Oct 17, 2018·European Journal of Endocrinology·C PetersN Schoenmakers
Jul 12, 2017·Annals of Pediatric Endocrinology & Metabolism·Il Soon ParkJin Soon Hwang
Nov 2, 2018·The Journal of Clinical Endocrinology and Metabolism·Lucie PépinRégis Coutant
Nov 18, 2018·EMBO Molecular Medicine·Athanasia StoupaAurore Carré
Mar 3, 2021·Endocrine·Athanasia StoupaAurore Carré
May 19, 2021·Médecine sciences : M/S·Juliane Léger
Jun 3, 2021·International Journal of Neonatal Screening·Keisuke NagasakiTadashi Asami
Jun 26, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Shao-Hong ChenFeng Wang
Nov 14, 2020·Environmental Science & Technology·Christopher D KassotisHeather M Stapleton
Oct 16, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Flora TzifiChristina Kanaka-Gantenbein
Apr 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Halef Okan Dogan, Mehmet Eray Alcigir
Oct 13, 2021·The Journal of Clinical Endocrinology and Metabolism·Juliane LégerJean-Claude Carel
Dec 2, 2021·The Journal of Clinical Endocrinology and Metabolism·Yaya BarryNolwenn Regnault
Sep 23, 2018·Pediatrics·Niamh McGrathNuala P Murphy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.