Increased incidence of gestational hypertension and preeclampsia after assisted reproductive technology treatment

Fertility and Sterility
Y A WangE A Sullivan

Abstract

To determine the association between assisted reproductive technology (ART) treatment and the rate of combined gestational hypertension (GH), preeclampsia (PE). Retrospective population study. Not applicable. A total of 596,520 mothers (3.6% ART mothers) who gave birth between 2007 and 2011. Not applicable. Comparison of the rate of GH/PE for ART and non-ART mothers, with odds ratio (OR), adjusted odds ratio (AOR), and 95% confidence interval (CI) used to assess the association between ART and GH/PE. The overall rate of GH/PE was 4.3%, with 6.4% for ART mothers and 4.3% for non-ART mothers. The rate of GH/PE was higher for mothers of twins than singletons (12.4% vs. 5.7% for ART mothers; 8.6% vs. 4.2% for non-ART mothers). The ART mothers had a 17% increased odds of GH/PE compared with the non-ART mothers (AOR 1.17; 95% CI, 1.10-1.24). After stratification by plurality, the difference in GH/PE rates between ART and non-ART mothers was not statistically significant, with AOR 1.05 (95% CI, 0.98-1.12) for mothers of singletons and AOR 1.10 (95% CI, 0.94-1.30) for mothers of twins. The changes in AOR after stratification indicated that multiple pregnancies after ART are the single most likely explanation for the increased rate of G...Continue Reading

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