Increased incidence of moderate stenosis among patients with diabetes: substrate for myocardial infarction?

American Heart Journal
P HenryJ L Guermonprez

Abstract

Persons with diabetes are at higher risk for myocardial infarction and sudden death than are persons without diabetes. It has been demonstrated that the artery that occludes during acute myocardial infarction generally had less than 75% stenosis on a previous angiogram. The extent of coronary artery stenosis was analyzed for 820 consecutively examined patients who underwent coronary angiography at our institution. The patients were categorized according to the presence or absence of diabetes mellitus. The severity of stenosis was taken into consideration. Patients with diabetes had moderate (50% to 75% narrowing) stenosis much more frequently than patients without diabetes (50.6 versus 30.3%, p < 0.001). Moreover diabetes mellitus was an independent risk factor for moderate stenosis. The lesions were more frequently located on distal arteries, more frequently had a pattern of three-vessel disease, and had a trend toward more diffuse disease than described 25 years ago. This greater amount of moderate stenosis may be considered a substrate for future acute plaque rupture. It may explain the high prevalence of acute myocardial infarction and sudden death among patients with diabetes without an increase in the incidence of angina ...Continue Reading

References

Nov 3, 1978·JAMA : the Journal of the American Medical Association·J E GalbraithN de Soyza
Jan 1, 1979·Circulation·W B Kannel, D L McGee
Jun 1, 1975·Annals of Internal Medicine·J SagelM Laimins
Sep 1, 1992·Journal of the American College of Cardiology·R M Jacoby, R W Nesto
Jul 1, 1988·Journal of the American College of Cardiology·J A AmbroseV Fuster
Jan 1, 1987·Cardiology·W B Kannel
Mar 22, 1984·The New England Journal of Medicine·UNKNOWN CASS Principal Investigators and Their Associates
Jan 16, 1982·British Medical Journal·L M Shapiro
Oct 16, 1980·The New England Journal of Medicine·M A DeWoodH T Lang
Jul 25, 1996·The New England Journal of Medicine·UNKNOWN Bypass Angioplasty Revascularization Investigation (BARI) Investigators
May 24, 2003·Current Diabetes Reports·Mihaela C BlendeaJames R Sowers

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Citations

Aug 27, 2003·Metabolism: Clinical and Experimental·Irina OtelNicolas Danchin
Jul 27, 2004·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Peter AmmannHans Rickli
Jan 15, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Timm BauerAnselm K Gitt
Dec 8, 2004·La Revue de médecine interne·P CosnayD Casset-Senon
Feb 17, 2000·Journal of the American College of Cardiology·M ShechterS Kaul
May 10, 2001·Journal of the American College of Cardiology·F LedruB Diébold
Apr 10, 2012·International Journal of Cardiology·Christoph H SaelyHeinz Drexel
Oct 27, 2006·Diabetes Care·Trevor J OrchardRichard W Nesto
Apr 25, 2007·Annals of Medicine·Marit GranérMarja-Riitta Taskinen
Sep 25, 1999·Japanese Circulation Journal·T TakezakoK Arakawa
Jun 28, 2005·European Heart Journal·Xavier JouvenDavid S Siscovick
May 15, 2008·Hormones : International Journal of Endocrinology and Metabolism·Katerina SaltikiMaria Alevizaki
Jul 1, 2018·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Preeti GuptaAtul Kapoor

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