Increased incidence of systemic serious viral infections in patients with inflammatory bowel disease associates with active disease and use of thiopurines.

United European Gastroenterology Journal
Andrew Wisniewskithe Saint-Antoine IBD network

Abstract

The magnitude and drivers of the risk of serious viral infections in Inflammatory Bowel diseases (IBD) are unclear. The objective of this study was to assess the incidence and risk factors for systemic serious viral infections in IBD patients. Using MICISTA, a database detailing prospective characteristics and complications of IBD, we identified patients that were followed for IBD in 2005-2014 outside the context of organ transplantation, HIV infection or chronic viral hepatitis. We estimated incidences of systemic serious viral infections, defined by the need for hospitalization or permanent organ damage. Standardized incidence ratios (SIRs) were calculated using the French hospital database. We performed a case-control study nested in MICISTA for assessing the role of exposure to IBD drugs and IBD clinical activity in the risk of developing infection. We identified 31 patients with serious viral infections among 2645 patients followed for 15,383 person-years. We observed 13 cases of cytomegalovirus, 10 Epstein-Barr virus, 5 varicella zoster virus and 3 herpes simplex virus infections. No deaths occurred. The incidence rate of infections in patients with IBD was 2.02/1000 person-years, and the SIR was 3.09 (95% confidence inte...Continue Reading

References

Mar 27, 2001·Gastroenterology·J CosnesJ P Gendre
Jul 27, 2001·The American Journal of Gastroenterology·K A PapadakisE A Vasiliauskas
Jun 1, 2004·Inflammatory Bowel Diseases·Didier ReijasseLaurent Beaugerie
Aug 29, 2006·Pediatric Blood & Cancer·Jan-Inge HenterGritta Janka
Dec 13, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Gauree GuptaJames D Lewis
Feb 26, 2008·Gastroenterology·Murat TorunerLaurence J Egan
Jul 11, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Valeria D'OvidioRenzo Caprilli
Dec 6, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·C SpringfeldP Schnitzler
Oct 19, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mario CottoneAmbrogio Orlando
Aug 15, 2012·The American Journal of Gastroenterology·Gary R LichtensteinWilliam J Sandborn
Dec 18, 2012·Alimentary Pharmacology & Therapeutics·M D LongM D Kappelman
May 8, 2013·The American Journal of Gastroenterology·Alexander C Ford, Laurent Peyrin-Biroulet
Feb 17, 2015·Alimentary Pharmacology & Therapeutics·K SagerC S Probert
Mar 1, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mark T OstermanJames D Lewis
Apr 12, 2017·The Lancet. Gastroenterology & Hepatology·Britta Siegmund
Jan 9, 2018·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nabeel KhanYu-Xiao Yang
Feb 24, 2018·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nghia H NguyenSiddharth Singh
Apr 16, 2018·Gastroenterology·Julien KirchgesnerRosemary Dray-Spira
Jul 22, 2018·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Laurent Beaugerie, Julien Kirchgesner
Aug 11, 2018·Alimentary Pharmacology & Therapeutics·Ruth de FranciscoSabino Riestra

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Citations

Aug 29, 2020·Expert Review of Gastroenterology & Hepatology·Shrihari Anil AnikhindiAnil Arora
Mar 28, 2020·Nature Reviews. Gastroenterology & Hepatology·Silvio DaneseAntonino Spinelli
May 14, 2020·The Medical Journal of Australia·Thomas M GoodsallRobert V Bryant
May 3, 2020·Alimentary Pharmacology & Therapeutics·Carlos TaxoneraEnrique Rey
Apr 23, 2020·Clinics·Natália Sousa Freitas QueirozAderson Omar Mourão Cintra Damião
Aug 28, 2020·Alimentary Pharmacology & Therapeutics·Carlos TaxoneraCristina Alba
Dec 6, 2020·United European Gastroenterology Journal·Joost Ph Drenth, Markus M Lerch
Dec 19, 2020·Scientific Reports·Satohiro Matsumoto, Hirosato Mashima
Nov 21, 2020·Gut·Charlie W LeesLaurent Beaugerie
Jan 17, 2021·Viruses·Georges TarrisGaël Belliot
Mar 13, 2021·The Lancet. Gastroenterology & Hepatology·Jonathan P SegalMatthew J Brookes
Oct 22, 2020·Journal of Crohn's & Colitis·A De Lima-KaragiannisC J van der Woude
Mar 30, 2021·World Journal of Gastroenterology : WJG·Júlio Maria Fonseca ChebliRogério Serafim Parra
Jun 13, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Fabio Salvatore MacalusoMassimo Galli
Jun 25, 2021·Aging Clinical and Experimental Research·Margalida CalafatEugeni Domènech
Aug 3, 2021·Frontiers in Medicine·Carla J Gargallo-PuyueloFernando Gomollón
Aug 10, 2021·World Journal of Gastroenterology : WJG·Vincenzo CraviottoMariangela Allocca
Sep 3, 2021·Alimentary Pharmacology & Therapeutics·Jayne DohertyGlen A Doherty
Sep 4, 2021·The European Respiratory Journal·Daniel WardTine Jess
Jul 1, 2021·United European Gastroenterology Journal·Fernando MagroKeith Siau
Sep 29, 2020·Inflammatory Intestinal Diseases·Karoline Soares GarciaAytan Miranda Sipahi
Jul 10, 2021·Gut and Liver·Yoo Jin LeeUNKNOWN Crohn's and Colitis Association in Daegu-Gyeongbuk (CCAiD)

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Methods Mentioned

BETA
PCR

Software Mentioned

MICISTA

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