Increased infiltration of CCR4-positive regulatory T cells in prostate cancer tissue is associated with a poor prognosis

The Prostate
Masahito WatanabeMakoto Sumitomo

Abstract

Regulatory T cells (Tregs) play important roles in the suppression of immune responses, including antitumor immune responses. C-C chemokine receptor 4 (CCR4) is highly expressed on effector Tregs, and anti-CCR4 antibody is attracting attention as a novel immunotherapeutic agent for solid tumors. This study aimed to evaluate the expression of CCR4-positive Tregs (CCR4+Tregs) in prostate cancer and estimate the clinical potential of CCR4-targeting therapy for prostate cancer. A total of 15 radical prostatectomy (RP) specimens and 60 biopsy specimens from individuals diagnosed with prostate cancer were analyzed to evaluate the infiltration of CCR4+Tregs in prostate cancer. The relationships between the number of CCR4+Tregs and clinical parameters were investigated in RP and biopsy specimens. Moreover, the total number of Tregs, CCR4+Tregs, and T cells and the ratio of CCR4+Tregs to Tregs and T cells in biopsy specimens were compared between patients with poor prognosis who progressed to castration-resistant prostate cancer (CRPC) within 12 months (n = 13) and those with good prognosis who were stable with hormone-sensitive prostate cancer over 12 months (n = 47). Furthermore, biopsy specimens were divided into two groups: low and ...Continue Reading

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Citations

Jun 1, 2020·Journal for Immunotherapy of Cancer·John P LynesEdjah K Nduom
Aug 13, 2020·International Journal of Molecular Sciences·Jan KorbeckiIrena Baranowska-Bosiacka
Aug 23, 2020·Journal of Clinical Medicine·Koji HatanoNorio Nonomura
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Jan 30, 2021·Life Sciences·Vahid KarpishehFarhad Jadidi-Niaragh
Feb 22, 2021·Human Immunology·Alexey Churov, Galina Zhulai
May 1, 2021·Cancers·Justine CinierChristine Ménétrier-Caux
May 1, 2021·Journal of Personalized Medicine·Katalin BalázsKatalin Lumniczky
Jul 9, 2021·International Journal of General Medicine·Yongrui Zhang, Yaowen Fu
Jul 10, 2021·Nature Reviews. Urology·Philipp WolfToni Cathomen
Jul 31, 2020·Combinatorial Chemistry & High Throughput Screening·Nan LiDingyuan Zeng

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