Increased inflammation, endoplasmic reticulum stress and oxidative stress in endothelial and macrophage cells exacerbate atherosclerosis in ApoCIII transgenic mice

Lipids in Health and Disease
Han YingchunZhang Xiaohong

Abstract

Overexpression of apolipoprotein CIII (ApoCIII) leads to hypertriglyceridemia (HTG) which promotes atherosclerosis development. However, it remains unclear whether ApoCIII affects the atherosclerosis alone by promoting the inflammation and endoplasmic reticulum (ER) stress, or in combination with HTG. Transgenic (ApoCIIItg) mouse models were used to investigate the atherogenic role of ApoCIII. Since endothelial cells and macrophages play crucial roles in atherosclerosis, we examined whether triglyceride-rich lipoproteins (TRLs), the major lipoproteins, in plasma of ApoCIIItg mice affect inflammation and ER stress levels in these cells. To further investigate the role of ApoCIII and triglyceride, we incubated HUVECs cells and peritoneal macrophages with TRLs with or without ApoCIII. Increased inflammation and ER stress were found in the aorta of ApoCIIItg mice. TRLs increased ER stress and oxidative stress in HUVECs and macrophages in a dose dependent. Moreover, TRLs together with ApoCIII could induce a higher inflammation level than TRLs alone in these cells. Both TRLs and ApoCIII contribute to the progression of atherosclerosis, and the modulation of TRLs and ApoCIII may represent a novel therapeutic approach against HTG induc...Continue Reading

References

Sep 1, 1979·Circulation·D B Zilversmit
Dec 1, 1991·The Journal of Clinical Investigation·J L Witztum, D Steinberg
Jul 20, 2007·JAMA : the Journal of the American Medical Association·Børge G NordestgaardAnne Tybjaerg-Hansen
Jul 20, 2007·JAMA : the Journal of the American Medical Association·Sandeep BansalPaul M Ridker
Jun 19, 2013·Progress in Lipid Research·Kathleen M Botham, Caroline P D Wheeler-Jones
Jun 19, 2014·The New England Journal of Medicine·Jacy CrosbySekar Kathiresan
Jun 19, 2014·The New England Journal of Medicine·Anders Berg JørgensenAnne Tybjærg-Hansen
Dec 4, 2014·The New England Journal of Medicine·Daniel GaudetJoseph L Witztum
Jul 15, 2015·Journal of Atherosclerosis and Thrombosis·Ammara UsmanJonathan H Gillard
Feb 20, 2016·Circulation Research·Michael D Shapiro, Sergio Fazio
Jul 12, 2016·The Journal of Clinical Investigation·Philip L S M GordtsJeffrey D Esko

❮ Previous
Next ❯

Citations

Aug 28, 2020·Frontiers in Endocrinology·Debapriya Basu, Karin E Bornfeldt
Oct 23, 2019·BioMed Research International·Liang LiChao Feng
Sep 24, 2020·Oxidative Medicine and Cellular Longevity·Shengjie YangSongzi Wang
Mar 2, 2021·Experimental Gerontology·Diogo Rodrigues JimenesDébora de Mello Gonçales Sant'Ana
Oct 16, 2020·Metabolism: Clinical and Experimental·Laura D'ErasmoMarcello Arca

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy
PCR

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.