Increased Inflammatory Response in Association with the Initiation of Hemodialysis Compared with Peritoneal Dialysis in a Prospective Study of End-Stage Kidney Disease Patients

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
Kenneth YongWai Lim

Abstract

Large epidemiological studies have demonstrated an early survival advantage with the initiation of peritoneal dialysis (PD) compared to haemodialysis (HD). Chronic inflammation may contribute to atherosclerosis and cardiovascular (CVD) mortality in end-stage kidney disease (ESKD). We hypothesize that the initiation of HD in ESKD patients is associated with a greater inflammatory response compared with PD. To examine the effects of initiating HD and PD upon inflammation and CVD risk markers in ESKD patients. We performed a pilot prospective study on 75 predialysis CKD stage-5 subjects comparing the effects of HD and PD upon high sensitivity C-reactive protein (hsCRP), interleukin(IL)-12, IL-18 and pulse wave velocity (PWV). Study visits were conducted 3 - 6 months before (baseline) and after (follow-up) initiation of dialysis RESULTS: Thirty-nine and 36 patients were initiated on HD and PD respectively. HD patients were older than PD patients (65.1 ± 2.1 vs 57.7 ± 2.7 years; p = 0.03) but had similar baseline systolic blood pressure (SBP), pulse pressure (PP), hsCRP, IL-12, IL-18, and PWV. At follow-up, HD patients had significantly increased hsCRP levels [5.2(3.7, 7.3) vs 1.7(1.0, 2.8)g/L; p < 0.001] compared to PD. Follow-up b...Continue Reading

References

Jan 14, 1999·The New England Journal of Medicine·R Ross
Jul 8, 2000·Kidney International·A K CheungA S Levey
May 2, 2002·Kidney International. Supplement·Christoph WannerThomas Metzger
Jul 31, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alessandro Amore, Rosanna Coppo
Oct 3, 2002·Seminars in Dialysis·Peter Stenvinkel, Anders Alvestrand
Feb 4, 2003·Nature Reviews. Immunology·Giorgio Trinchieri
Apr 16, 2003·Kidney International. Supplement·Gérard M LondonBruno Pannier
Jul 31, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter JacobsRaymond Vanholder
Jun 17, 2006·Nature Reviews. Immunology·Göran K Hansson, Peter Libby
Sep 27, 2006·European Heart Journal·Stephane LaurentUNKNOWN European Network for Non-invasive Investigation of Large Arteries
Nov 3, 2006·Kidney International. Supplement·E F VoneshA J Collins
Sep 9, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tomasz PorazkoMarian Klinger
Nov 11, 2008·The New England Journal of Medicine·Paul M RidkerUNKNOWN JUPITER Study Group
Dec 19, 2008·Journal of the American Society of Nephrology : JASN·Stephen P McDonaldKevan R Polkinghorne
Dec 29, 2009·The International Journal of Artificial Organs·Vassilis FiliopoulosDimosthenis Vlassopoulos
Feb 13, 2010·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Michael F FlessnerJeffrey Henegar
Jan 31, 2012·Current Pharmaceutical Design·D Di RaimondoA Pinto
Apr 27, 2012·Kidney International·Marie BrietGérard M London
Oct 12, 2013·Frontiers in Immunology·Charles A DinarelloGilles Kaplanski
Nov 10, 2013·European Heart Journal·Paul M Ridker
Sep 21, 2016·Journal of the American Society of Nephrology : JASN·Kristen L NowakAdriana M Hung

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Citations

Sep 28, 2018·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Dugan W MadduxFranklin W Maddux
Jul 13, 2019·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Matthew R LozierGabriel A Valle
Jan 23, 2019·Anesthesiology and Pain Medicine·Shervin FarahmandAlireza Baratloo
Jul 21, 2020·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Alexandre CandellierÉric Goffin
Jan 28, 2021·The Cochrane Database of Systematic Reviews·Htay HtayYeoungjee Cho

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Methods Mentioned

BETA
enzyme-linked immunoassay

Software Mentioned

SPSS

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