PMID: 9553182Jun 13, 1998Paper

Increased insulin-like growth factor-I mRNA expression in pyloric muscle in infantile hypertrophic pyloric stenosis

Pediatric Surgery International
K Ohshiro, P Puri

Abstract

The etiology of infantile hypertrophic pyloric stenosis (IHPS) is unknown. Insulin-like growth factor-I (IGF-I) is a polypeptide hormone that elicits various biological activities (cellular growth, replication, and differentiation) by binding to its receptors. IGF-I has been suggested to play an important role in both gastrointestinal (GI) maturation and smooth-muscle-cell (SMC) hypertrophy. Full-thickness muscle biopsy specimens were obtained from 8 IHPS patients (age range 14-64 days, mean 28.1 days) at pyloromyotomy and from 8 age-matched controls (15-60 days, mean 33.8 days) without GI disease at autopsy. In-situ hybridization was performed using an IGF-I-specific and digoxigenin (DIG)-labeled oligonucleotide probe and visualized by nitroblue tetrazolium staining. In normal controls, IGF-I mRNA expression was absent or weak in both circular and longitudinal smooth-muscle layers of pyloric muscle. In contrast, the pyloric muscle in IHPS patients demonstrated strong IGF-I mRNA expression in the circular smooth-muscle layer and moderate expression in the longitudinal smooth-muscle layer. The increase in IGF-I mRNA in pyloric muscle in IHPS suggests that SMCs are actively synthesizing IGF-I, contributing to the development of p...Continue Reading

Citations

May 19, 2009·Pediatric Radiology·Marta Hernanz-Schulman
Sep 18, 2009·Pediatric Surgery International·Christina Panteli
May 21, 2013·Pediatric Surgery International·Salvatore CascioRobert Carachi
Mar 15, 2003·Radiology·Marta Hernanz-Schulman
Dec 14, 2002·Anatomia, histologia, embryologia·R M AbelL Spitz
Apr 20, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D Ramkumar, K S Schulze
Jan 11, 2007·Seminars in Pediatric Surgery·Gudrun Aspelund, Jacob C Langer
Oct 17, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Manfred Hauben, Guy W Amsden
Aug 7, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·John F Kuemmerle

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