Increased insulin receptor expression in anterior temporal neocortex of patients with intractable epilepsy

Journal of the Neurological Sciences
Liang WangXuefeng Wang

Abstract

The insulin receptor (IR) is a tyrosine kinase receptor that binds to insulin and plays pivotal roles in energy homeostasis, neuronal growth, neuronal survival, synaptic plasticity and cognitive function. The biological mechanisms of intractable epilepsy involve energy metabolism, neuron loss, neurogenesis and abnormal neural networks. Here, we evaluated the expression of the IR in the anterior temporal neocortex of patients with intractable epilepsy (IE) by immunohistochemistry, double-label immunofluorescence and immunoblotting. We compared these tissues against histologically normal anterior temporal lobes from individuals treated for post-trauma intracranial hypertension. We found that the IR was coexpressed with neuron-specific enolase (NSE) and that IR expression increased in the anterior temporal neocortex of epileptic patients. On the basis of the potential physiological effects of IR, our findings suggest that increased expression of the IR is a consequence of epileptic seizures and a cause of IE.

References

Mar 1, 1981·Diabetologia·J HavrankovaJ Roth
Apr 1, 1994·Acta Paediatrica. Supplement·S I TaylorE Wertheimer
Aug 1, 1997·The Journal of Biological Chemistry·M Hong, V M Lee
Apr 21, 1999·Epilepsy Research·G Regesta, P Tanganelli
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·V A SkeberdisM V Bennett
Oct 13, 2001·Neuroendocrinology·W KernH L Fehm
Mar 30, 2002·Current Opinion in Neurology·Wolfram S Kunz
Apr 8, 2003·Current Pharmaceutical Design·Stephen C WoodsMichael W Schwartz
Dec 6, 2003·Science·Morris F White
Apr 20, 2004·European Journal of Pharmacology·William A Banks
Mar 1, 2005·Trends in Endocrinology and Metabolism : TEM·Leona PlumJens C Brüning
Jun 11, 2005·Epilepsia·Dieter Schmidt, Wolfgang Löscher
Aug 19, 2006·Progress in Neurobiology·Lars P van der HeideMarten P Smidt
Aug 29, 2006·Biochemical and Biophysical Research Communications·Jin-Mei LiHong-Wei Li
Jul 31, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Z-Q XiL-F Guan
Aug 23, 2008·Neurochemical Research·Liang WangZheng Xiao
Apr 11, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Igor TimofeevDragos A Nita

❮ Previous
Next ❯

Citations

Apr 3, 2012·The American Journal of Pathology·Yali XuGuojun Chen
Jan 19, 2017·Reviews in the Neurosciences·Mojdeh NavidhamidiNasrin Mehranfard

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.