Increased insulin receptors after exercise in patients with insulin-dependent diabetes mellitus

The New England Journal of Medicine
O PedersenL Heding

Abstract

Physical exercise is known to improve glucose tolerance and diminish insulin requirements in patients with well-controlled diabetes mellitus. To ascertain whether these effects of exercise are associated with alterations in insulin receptors, we studied [125I]insulin binding to erythrocytes and monocytes in athletically untrained young men with insulin-treated diabetes during three hours of postprandial bicycle exercise (nine patients) and two hours of exercise during fasting (eight patients). Compared with control periods, postprandial exercise, as well as exercise during fasting, significantly increased insulin binding to erythrocytes and monocytes at an insulin-tracer concentration of 34 pmol per liter. We suggest that similar changes occur in working muscle cells and contribute to the improved glucose tolerance induced by exercise.

References

Nov 1, 1976·Acta Endocrinologica·O Pedersen, H Beck-Nielsen
Jul 1, 1978·The Journal of Clinical Investigation·R A DeFronzoP Felig
Feb 1, 1979·Diabetes·M Vranic, M Berger
Jul 1, 1978·The Journal of Clinical Endocrinology and Metabolism·V R SomanP Felig
Aug 1, 1978·The Journal of Clinical Endocrinology and Metabolism·H Beck-Nielsen, O Pedersen
Oct 1, 1979·The Journal of Clinical Investigation·V A KoivistoP Felig
Nov 29, 1979·The New England Journal of Medicine·V R SomanR A DeFronzo
Dec 1, 1977·Diabetologia·H Beck-NielsenN S Sorensen
Mar 1, 1978·Metabolism: Clinical and Experimental·N KalantK McNeil
May 1, 1978·Diabetes·R I MisbinT J Merimee
Jul 1, 1978·Diabetes·K K GambhirC J Bradley
Oct 27, 1975·Biochemical and Biophysical Research Communications·P De Meyts, J Roth
May 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A H Christiansen
Oct 1, 1973·Scandinavian Journal of Clinical and Laboratory Investigation·E D Pruett, S Maehlum

❮ Previous
Next ❯

Citations

Jan 1, 1983·Human Genetics·H W Rüdiger, M Dreyer
Jan 1, 1984·European Journal of Clinical Pharmacology·K TöttermanF Fyhrquist
Jan 1, 1985·European Journal of Clinical Pharmacology·K HarnoM Verho
Apr 2, 1984·Klinische Wochenschrift·E A ChantelauM Berger
Sep 29, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·P Damm, C Binder
Mar 22, 1984·Biochimica Et Biophysica Acta·A Dwenger, R Zick
Jan 1, 1988·The International Journal of Biochemistry·G Serck-HanssenR T Lie
Apr 30, 1981·The New England Journal of Medicine·O PedersenH Kromann
Feb 1, 1991·European Journal of Clinical Investigation·G AnnuzziL Kaijser
Mar 20, 1993·BMJ : British Medical Journal·T P Chua, D P Lipkin
Apr 1, 1982·The Journal of Clinical Investigation·E A RichterN B Ruderman
Oct 16, 2012·Cell Communication and Signaling : CCS·Naohiro YanoYi-Tang Tseng
May 1, 1982·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·A DwengerI Trautschold
Nov 1, 1984·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·S W GolfK E Seim
Oct 1, 1986·American Journal of Obstetrics and Gynecology·S O SkoubyC Kühl
Aug 1, 1989·American Journal of Obstetrics and Gynecology·L Jovanovic-PetersonC M Peterson
Dec 1, 1980·Kidney International·A P GoldbergH R Harter
Oct 3, 2008·Pediatric Diabetes·Jaime S Rosa, Pietro R Galassetti
Jan 1, 1984·Preventive Medicine·R S Paffenbarger, R T Hyde
Dec 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A K Dutta-Roy
Jan 1, 1986·Diabetes/metabolism Reviews·J O HolloszyD A Young
Jan 1, 1986·Diabetes/metabolism Reviews·S H SchneiderN Ruderman
Jan 1, 1986·Diabetes/metabolism Reviews·V A KoivistoR A DeFronzo
Jan 1, 1986·Diabetes/metabolism Reviews·F W Kemmer, M Berger
Sep 1, 1984·Diabetic Medicine : a Journal of the British Diabetic Association·R Taylor
Jul 1, 1982·Clinical Endocrinology·E A BensonI M Holdaway
Jan 1, 1984·Clinical Endocrinology·B L WajchenbergI T Toledo e Souza
Jul 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·B N Campaigne, R Gunnarsson
Feb 1, 1994·Baillière's Clinical Rheumatology·P Katz
Mar 1, 1996·Obstetrics and Gynecology Clinics of North America·L Jovanovic-Peterson, C M Peterson
Mar 1, 1983·Clinics in Endocrinology and Metabolism·G GrunbergerP Gorden
Apr 26, 1985·The American Journal of Cardiology·R S Williams

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.