Increased intensities of fas expression on peripheral T-cell subsets in severe autoimmune thyroid disease

Thyroid : Official Journal of the American Thyroid Association
Hayato MaruokaYoshinori Iwatani

Abstract

Fas (CD95)-Fas ligand (FasL; CD178)-induced apoptosis is necessary for the maintenance of self-tolerance. To clarify whether or not any abnormalities in the Fas-FasL system exist in patients with autoimmune thyroid disease (AITD), we examined the expression of Fas and FasL on peripheral T lymphocytes by three-color flow cytometry in 113 patients with AITD and 49 healthy controls. The intensities of Fas expression in both CD4(+) and CD8(+) T cells decreased in thyrotoxic patients with Graves' disease (GD), but increased in both patients with severe Hashimoto's disease (HD) undergoing treatment and seriously intractable patients with GD continuously positive for thyrotropin (TSH) receptor antibody despite treatment with antithyroid drugs for more than 5 years. The proportion of Fas expression was increased in CD4(+) T cells from patients with untreated GD, and in CD8(+) T cells from patients with severe HD. The proportion of CD8(+) T cells decreased in patients with severe HD. FasL were not expressed on T cells in controls and patients with AITD. These results indicate that (1). the intensities of Fas expression on peripheral T cells increase in severe autoimmune thyroid diseases and (2). both the intensity and the proportion of ...Continue Reading

References

Jan 1, 1991·Thyroid : Official Journal of the American Thyroid Association·T FrancisK D Burman
Feb 1, 1986·The Journal of Clinical Endocrinology and Metabolism·J Y Chan, P G Walfish
Nov 17, 1995·Science·T S GriffithT A Ferguson
Mar 1, 1994·The Journal of Clinical Investigation·E MyslerK B Elkon
Jan 1, 1995·The Journal of Experimental Medicine·M R AldersonD H Lynch
Dec 1, 1995·Immunology Today·D H LynchM R Alderson
Dec 1, 1996·Journal of Neuroimmunology·H IchikawaM Iwata
Oct 1, 1996·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·S Nagata
Jan 24, 1998·The Journal of Allergy and Clinical Immunology·T Suda, S Nagata
Aug 28, 1998·Mechanisms of Ageing and Development·M PotestioG C Romano
Nov 25, 1998·Seminars in Immunology·N Moulian, S Berrih-Aknin
May 13, 1999·Thyroid : Official Journal of the American Thyroid Association·Y HiromatsuK Nonaka
Aug 7, 1999·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J FeldkampW A Scherbaum
May 8, 2000·Transplantation·A I ColovaiN Suciu-Foca
Mar 3, 2001·The New England Journal of Medicine·T Kamradt, N A Mitchison
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M HaraK J Wood
May 5, 2001·Immunity·X C LiA D Wells
Dec 17, 2002·Thyroid : Official Journal of the American Thyroid Association·Mikio WatanabeYoshinori Iwatani
May 6, 2003·Thyroid : Official Journal of the American Thyroid Association·Mikio WatanabeYoshinori Iwatani
Jun 14, 2003·Thyroid : Official Journal of the American Thyroid Association·Yumi NakamotoYoshinori Iwatani

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Citations

Sep 29, 2007·Thyroid : Official Journal of the American Thyroid Association·Su He Wang, James R Baker
Feb 6, 2008·Endocrine Journal·Mikio WatanabeYoshinori Iwatani
Feb 6, 2007·Thyroid : Official Journal of the American Thyroid Association·Aiko NakanoYoshinori Iwatani

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Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

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