PMID: 11122256Dec 21, 2000Paper

Increased interferon-gamma (IFN-gamma), IL-10 and decreased IL-4 mRNA expression in peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE)

Clinical and Experimental Immunology
A CsiszárE Pócsik

Abstract

Cytokines are important regulators of lymphocyte function in SLE. However, the profile of Th1 and Th2 cytokines produced by circulating lymphocytes in human SLE has not been clearly elucidated. The aim of the present study was to characterize the gene expressions of the Th1-type cytokine IFN-gamma, and the Th2-type cytokines IL-10 and IL-4 in PBMC of 15 patients with SLE and 10 healthy individuals by a semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR). Our results showed that expression of IFN-gamma (P = 0.0004) and IL-10 (P = 0.002) transcripts were significantly increased in PBMC of patients with SLE compared with healthy controls. By contrast, expression of IL-4 transcripts in PBMC of patients with SLE was significantly decreased compared with the healthy controls (P = 0.0008). Primary sources of IL-10 were B cells and monocytes, with variable contribution of T cells as detected in various fractions of PBMC of patients with SLE (P = 0.049). These findings support the hypothesis that the enhanced production of IFN-gamma by mononuclear cells may trigger inflammatory responses, together with the enhanced production of IL-10 resulting in autoantibody production by B cells in human SLE.

References

Jul 1, 1992·Journal of Clinical Immunology·M HowardJ de Vries
Mar 1, 1992·European Journal of Immunology·A O'GarraM Howard
Sep 1, 1992·Clinical Immunology and Immunopathology·R OrE W Gelfand
Jan 1, 1991·International Archives of Allergy and Applied Immunology·A MoriH Okudaira
Jan 1, 1986·Springer Seminars in Immunopathology·A N TheofilopoulosF J Dixon
Sep 1, 1987·The Journal of Experimental Medicine·C O JacobH O McDevitt
Jun 1, 1987·The Journal of Experimental Medicine·D M Klinman, A D Steinberg
Jan 1, 1985·Advances in Immunology·A N Theofilopoulos, F J Dixon
May 1, 1995·Journal of Clinical Immunology·S Romagnani
Jan 1, 1993·Immunologic Research·L ImbertiD Primi
Jan 1, 1993·Journal of Clinical Immunology·M al-JanadiS Raziuddin
May 1, 1993·Molecular Immunology·C G GarlisiS P Umland
Aug 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·H U SchorlemmerK H Enssle
Jun 1, 1996·The Journal of Allergy and Clinical Immunology·L BorishS Wenzel
Jan 1, 1996·Immunologic Research·M P Piccinni, S Romagnani
Sep 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J Van WauweM de Boer
Apr 15, 1997·The Journal of Clinical Investigation·S L PengJ Craft
Nov 14, 1997·Scandinavian Journal of Immunology·A E MonganR J Warrington
Mar 24, 1998·Molecular Human Reproduction·K J LimI D Cooke
Jun 30, 1998·Scandinavian Journal of Rheumatology·M FunauchiA Horiuchi
Apr 13, 1999·Critical Care Medicine·T KawamuraS Endo
May 13, 1999·Scandinavian Journal of Immunology·S HodgeP Han
Jul 23, 1999·Annals of the New York Academy of Sciences·M Ostensen
Apr 19, 2000·The Journal of Clinical Endocrinology and Metabolism·E J GiltayL J Gooren

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Citations

Apr 30, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Monika SlavikovaPeter Kontsek
Aug 5, 2009·Rheumatology·Wahid Ali KhanHarvinder S Chabbra
Jul 2, 2011·Current Opinion in Rheumatology·Min S ShinInsoo Kang
Jul 2, 2003·Journal of Clinical Pathology·C C Mok, C S Lau
Jul 14, 2010·Journal of Biomedicine & Biotechnology·Zhe ZhangKathleen E Sullivan
Oct 12, 2010·Journal of Biomedicine & Biotechnology·Chary López-PedreraMaria José Cuadrado
Jul 30, 2008·Current Rheumatology Reports·Joan T Merrill
Jun 1, 2005·Rheumatic Diseases Clinics of North America·Andrea L SestakJohn B Harley
Aug 24, 2007·Clinical Rheumatology·Marut TangwattanachuleepornNattiya Hirankarn
Jan 7, 2006·Rheumatology International·Eren ErkenRamazan Gunesacar
Sep 11, 2012·Journal of Clinical Immunology·Lijun SongXingfu Li
Jun 10, 2004·Pathology Oncology Research : POR·Anna CsiszárEva Pócsik
May 3, 2008·Modern Rheumatology·Yingge WangTakayuki Sumida
Apr 29, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Yinglu FengChangquan Ling
Sep 26, 2014·Clinical and Experimental Medicine·Claudia Azucena Palafox-SánchezJosé Francisco Muñoz-Valle
Feb 10, 2009·Cytometry. Part B, Clinical Cytometry·Susana Mellor-PitaJuan A Vargas
Oct 4, 2007·Annals of the New York Academy of Sciences·Michele MondiniSanto Landolfo
Sep 24, 2011·Clinical & Developmental Immunology·Chary López-PedreraMa José Cuadrado
Jan 18, 2006·European Journal of Pharmacology·Chih-Peng LiuYuh-Chi Kuo
Sep 10, 2005·Best Practice & Research. Clinical Rheumatology·Joan T Merrill, Jill P Buyon
Apr 14, 2016·The Journal of Experimental Medicine·Phillip P DomeierZiaur S M Rahman
Jan 18, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Alexandros P GrammatikosGeorge C Tsokos
Dec 30, 2014·Cellular Immunology·Kira RubtsovaAnatoly V Rubtsov
May 18, 2016·The Journal of Clinical Investigation·Jianxun WangMaria I Kontaridis
Feb 9, 2017·Autoimmunity·Phillip P DomeierZiaur S M Rahman
Dec 11, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·X Z CaiY Jiang
May 19, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·K H ChuaL H Lian
Oct 26, 2006·Scandinavian Journal of Rheumatology·G Valencia-PachecoR González-Amaro

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