Increased interhemispheric resting-state functional connectivity in paroxysmal kinesigenic dyskinesia: a resting-state fMRI study

Journal of the Neurological Sciences
Jiechuan RenDong Zhou

Abstract

Paroxysmal kinesigenic dyskinesia (PKD) is a rare movement disorder. The underlying neural mechanisms have not been fully understood. This study aimed to examine the alteration of resting-state functional connectivity (RSFC) between interhemispheric homotopic regions in PKD using a technique called "voxel-mirrored homotopic connectivity" (VMHC). The VMHC analysis was performed on resting-state functional MRI data from 11 PKD patients and 17 age and gender matched healthy subjects. Comparison between the two groups was conducted. The correlation relationship between VMHC and illness duration was analyzed. Compared with healthy subjects, PKD patients showed increased interhemispheric RSFC in bilateral putamen, primary motor cortex, supplementary motor area, dorsal lateral prefrontal cortex, primary somatosensory cortex, superior and middle occipital gyri, as well as cerebellar tonsil. Besides, negative correlation was detected between illness duration and VMHC in bilateral putamen and the insular cortex. The present study provided preliminary evidence of increased interhemispheric RSFC in PKD mainly in the basal ganglia-thalamo-cortical circuitry and cerebellum. A negative correlation between VMHC and illness duration was also de...Continue Reading

References

Jul 1, 1990·Trends in Neurosciences·G E Alexander, M D Crutcher
Oct 1, 1995·Annals of Neurology·M Demirkiran, J Jankovic
Oct 1, 1996·Brain Research. Brain Research Reviews·J R Augustine
Sep 25, 1998·Neurology·K J BlackJ S Perlmutter
May 14, 1999·Journal of Neurology·K P Bhatia
Aug 21, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·S ShiraneT Hashimoto
Feb 9, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Anne ThiriauxIzzie J Namer
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Jerrold L Vitek
Jun 11, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Eun Yeon JooByung Tae Kim
May 13, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·T EtgenD Sander
Apr 20, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Mark ObermannMatthias Maschke
Aug 2, 2008·Brain : a Journal of Neurology·Vladimir K NeychevH A Jinnah
Dec 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David E StarkMichael P Milham
Aug 1, 2009·Trends in Cognitive Sciences·Tania SingerKerstin Preuschoff
Aug 7, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Miklos ArgyelanDavid Eidelberg
Jun 26, 2010·Frontiers in Systems Neuroscience·Yan Chao-Gan, Zang Yu-Feng
Jul 16, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Bo ZhouDong Zhou
Nov 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xi-Nian ZuoMichael P Milham
Feb 10, 2011·Neurobiology of Disease·Vladimir K NeychevH A Jinnah
Apr 27, 2011·Human Brain Mapping·Cheng LuoDezhong Yao
Nov 29, 2011·Brain : a Journal of Neurology·Jun-Ling WangBei-Sha Tang
Apr 10, 2012·NeuroImage·Ryan D MooreMark Hallett
Aug 23, 2012·Schizophrenia Research·Matthew J HoptmanDaniel C Javitt
Nov 20, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Wenbin GuoChangqing Xiao
Jan 10, 2013·Journal of Neurology·Felicitas BeckerYvonne G Weber
Jul 31, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Angelo Quartarone, Mark Hallett
Jan 21, 2014·Neuropsychology Review·Philip Gerard Gasquoine
Jan 31, 2014·Brain : a Journal of Neurology·Karen E MurphyGlenda M Halliday

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Citations

Jul 22, 2016·Medicine·Julián Benito-LeónÁlvaro Sánchez-Ferro
Nov 12, 2019·Human Brain Mapping·Anna Elisabetta VaudanoStefano Meletti
Dec 15, 2015·Medicine·Julián Benito-LeónEduardo Rocon
May 12, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Xiao-Jun HuangLi Cao
Feb 12, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Zhiliang LongWei Liao
Nov 24, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Wei LiuGuangxiang Chen

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