Increased interleukin 1α and interleukin 1β expression is involved in the progression of periapical lesions in primary teeth

BMC Oral Health
Ning-Yan YangJia-Jian Shang

Abstract

Interleukin 1 (IL-1) is involved in bone resorption. However, the role of IL-1 in periapical lesions characterized by periapical bone destruction in primary teeth has not yet been fully elucidated. This study aimed to detect the distribution and expression of IL-1 in periapical lesions in primary teeth and assess the relationship between the cytokines and the degree of inflammatory cell infiltration. A total of 106 chronic periapical lesions in primary teeth were harvested. Haematoxylin and eosin (H&E) staining was used to determine the histological type and the inflammatory cell infiltration grade (mild, moderate, and severe), and immunohistochemistry and enzyme-linked immunosorbent assay (ELISA) were used to detect the distribution and expression of IL-1α and IL-1β. Of the 106 chronic periapical lesion samples, there were 85 cases of periapical granuloma, accounting for 80.19% of the total samples, and 21 cases of radicular cysts, accounting for 19.81%; no cases of abscess were detected. Immunohistochemistry results showed that both IL-1α and IL-1β were expressed in periapical granulomas and cysts. ELISA results showed that IL-1α and IL-1β levels were higher in the periapical granuloma group than in the radicular cyst and nor...Continue Reading

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Citations

Apr 11, 2019·Brazilian Dental Journal·Sidinéia Feitoza de JesusLéa Assed Bezerra da Silva
Nov 2, 2019·Cytokine·Mohammad M Y KhorasaniHossein Khorramdelazad
Mar 14, 2021·Photochemistry and Photobiology·Glauco Rodrigues Carmo SilveiraLeandro Araújo Fernandes
Mar 1, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ming DongWeidong Niu
Sep 18, 2021·International Endodontic Journal·Renan Dal-FabbroJoão Eduardo Gomes-Filho

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