Increased interleukin 23 (IL23) levels in schizophrenia patients treated with depot antipsychotic medication

Cytokine
Kara E O'ConnellKumlesh K Dev

Abstract

Schizophrenia is a mental disorder, where genetic and environmental factors contribute to disease onset and progression. The immune system appears to play a role in schizophrenia, where altered cytokines levels and autoantibodies have been described. Notably however, to our knowledge, IL23 levels have not before been measured in schizophrenia patients treated with depot medication. We examined IL23 levels in serum samples obtained from patients with schizophrenia, treated with depot medication (n=35) compared with healthy controls (n=38) and correlated these levels with treatment time, patient age and illness severity. IL23 levels were raised in depot treated groups compared with healthy controls. No correlation was observed, however, between IL23 levels and treatment time, patient age or illness severity. IL23 levels are raised in schizophrenia patients prescribed with depot medication, supporting the role of aberrant cytokine signalling in schizophrenia.

References

Nov 18, 2004·Immunological Reviews·Claire L LangrishDaniel J Cua
Apr 28, 2006·Archivum Immunologiae Et Therapiae Experimentalis·Carol Beadling, Mark K Slifka
Feb 20, 2009·The International Journal of Neuropsychopharmacology·Rushaniya A KhairovaHusseini K Manji
Dec 22, 2009·Expert Review of Neurotherapeutics·Roosmarijn C DrexhageHemmo A Drexhage
Apr 13, 2011·Molecular Psychiatry·E SchwarzS Bahn
May 28, 2013·BMC Psychiatry·Kara O'ConnellKumlesh K Dev
Apr 20, 2014·Schizophrenia Research·Kara E O'ConnellKumlesh K Dev

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Citations

Dec 3, 2016·Molecular Neurobiology·Monojit Debnath, Michael Berk
Jul 6, 2021·Indian Journal of Clinical Biochemistry : IJCB·Priya AllimuthuJesudas Blessed Raj

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