Abstract
Nonalcoholic fatty liver disease (NAFLD) currently represents the most common hepatic disease worldwide and is closely linked to cardiovascular disease, obesity and diabetes mellitus. This study aimed to investigate NAFLD and its influence on different monocyte subpopulations to determine the presence of significant associations. A total of 3 monocyte subpopulations were investigated, i.e. classical (CD14++CD16-), intermediate (CD14++CD16+) and non-classical (CD14+CD16++). Of the participants 261 were included in this study (n = 53 with NAFLD, n = 208 controls). Ultrasonography was used to diagnose NAFLD and exclude other morphologic causes of liver diseases and other tests (including medical history inquiries and detection of hepatitis virus) were performed to exclude other causes of parenchymal liver disease. Classical inflammatory and metabolic-related NAFLD biomarkers were also determined. In contrast to the healthy control group, the intermediate monocyte fraction was increased in NAFLD patients (p = 0.032), while the classical monocyte fraction was decreased (p = 0.025). Intermediate monocyte fraction, body mass index (BMI) and tumor necrosis factor alpha (TNF-α) were independent risk factors for NAFLD. Classical, non-cla...Continue Reading
References
Jan 15, 1997·Annals of Internal Medicine·S G ShethS Chopra
Sep 6, 2000·Clinical and Experimental Immunology·K KatayamaS Furukawa
Jun 22, 2002·Journal of Hepatology·Masahiko ShimadaJurgen Ludwig
Aug 21, 2003·The Journal of Dermatology·Hiroyuki OkamotoTakeshi Horio
Jan 30, 2004·Rheumatology·A L HepburnK A Davies
Jul 23, 2004·Thrombosis and Haemostasis·Axel SchlittHans J Rupprecht
Dec 3, 2005·Nature Reviews. Immunology·Siamon Gordon, Philip R Taylor
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Geoffrey C Farrell, Claire Z Larter
May 15, 2007·Gastroenterology·Steven E ShoelsonAfia Naaz
Oct 17, 2007·Digestive Diseases and Sciences·Cem AygunSadettin Hulagu
May 19, 2009·Journal of Hepatology·György Baffy
Jun 16, 2010·PloS One·Henning W ZimmermannFrank Tacke
Mar 16, 2011·The Tohoku Journal of Experimental Medicine·Hack-Lyoung KimDonghee Kim
Jun 10, 2011·Blood·Kok Loon WongSiew-Cheng Wong
Aug 2, 2011·Blood·Adam M ZawadaGunnar H Heine
Sep 29, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kazushi Sugimoto, Yoshiyuki Takei
Apr 26, 2012·BMC Gastroenterology·Sebastian SeidlerFrank Tacke
May 9, 2012·Journal of Diabetes·Ana C Tuyama, Charissa Y Chang
Jan 9, 2014·Biomarker Research·Jiyeon YangHong Wang
Apr 16, 2014·International Reviews of Immunology·Kolandaswamy AnbazhaganFlorence Apparailly
Apr 9, 2015·Clinical and Translational Medicine·Brian K Stansfield, David A Ingram
Sep 12, 2015·Scientific Reports·Ratnadeep MukherjeeBalachandran Ravindran
Feb 6, 2016·Reviews in Endocrine & Metabolic Disorders·Marina NatiAntonios Chatzigeorgiou
Citations
Mar 14, 2019·Metabolic Syndrome and Related Disorders·Konstantinos A ChristouStelios Tigas
Jul 14, 2020·Frontiers in Cellular Neuroscience·Xiuping LiMinshu Li
Feb 27, 2021·Frontiers in Immunology·Joeri Lambrecht, Frank Tacke
Mar 30, 2021·Neuropsychiatric Disease and Treatment·Kai-Qi DingLi-Li Zeng